Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation

Berrin Benli YAVUZ; Mehmet KOÇ; Sümeyye KOZACIOĞLU; Gül KANYILMAZ; Meryem AKTAN

Article Details

Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation

Authors:

Berrin Benli YAVUZ | Mehmet KOÇ | Sümeyye KOZACIOĞLU | Gül KANYILMAZ | Meryem AKTAN

Publisher:

TUBITAK

Main Topics:

Promotion of health

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1025-1032

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000749966

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim: This study aimed to describe the prognostic importance of epidermal growth factor (EGFR), phosphatase and tensin homolog (PTEN), human EGF receptor-2 (HER-2), and insulin-like growth factor 1 receptor (IGF-1R) in gastric cancer patients treated with postoperative chemoradiation therapy. Materials  and  methods:  Sixty-nine  patients  treated  with  adjuvant  chemoradiation  therapy  were  retrospectively  evaluated.  Tumor  samples were stained immunohistochemically. Results: All  patients  were  treated  with  3D  conformal  radiation  therapy  with  concomitant  and  adjuvant  chemotherapy.  Perineural  invasion (PNI) (P = 0.042), prechemoradiation therapy albumin levels below 3.5 mg/dL (P = 0.011), and EGFR positivity (P = 0.008) had negative effects on overall survival (OS). The median OS was 26 months for patients with PNI (+), 34.9 months for those with PNI (-), 19.5 months for those with albumin levels below 3.5 mg/dL, and 33.2 months for those with albumin levels above 3.5 mg/dL. IGF-1R (+) (P = 0.035) and history of cigarette smoking (P = 0.033) were observed to have a statistically significantly negative effect on disease-free survival (DFS). The median DFS was 29.2 months for IGF-1R (+) patients, 37.9 months for those with IGF-1R (-), and 26.3 and 40.59 months for smokers and nonsmokers, respectively. Conclusion: IGF-1R and EGFR may be used for patient selection in future prospective studies that evaluate the prognostic importance of these receptors.

Article Details

Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation

Authors: Berrin Benli YAVUZ | Mehmet KOÇ | Sümeyye KOZACIOĞLU | Gül KANYILMAZ | Meryem AKTAN

Publisher: TUBITAK

Main Topics: Promotion of health

Journal: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1025-1032

Document Type: Article

Publication Date: 7/2019

Document Language: English

Document ID (Org No.): 2000749966

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Berrin Benli YAVUZ | Mehmet KOÇ | Sümeyye KOZACIOĞLU | Gül KANYILMAZ | Meryem AKTAN

Publisher:

TUBITAK

Main Topics:

Promotion of health

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1025-1032

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000749966

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144