Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study

Ş. Efsun Antmen; Canan Çulha; Mesut Sancar; Sema Erden Ertürk; Necmiye Canacankatan; Mehmet Canacankatan

Article Details

Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study

Authors:

Ş. Efsun Antmen | Canan Çulha | Mesut Sancar | Sema Erden Ertürk | Necmiye Canacankatan | Mehmet Canacankatan

Publisher:

Duzce University

Main Topics:

Emergency Medicine

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.228-233

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329234

pISSN:

1307-671X

Keywords:

Abstract:

 Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments. Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software. Results: The median age of patients was 63 range, 19-96 years, with 55.4 n227 being female and 44.6 n183 were male. A total of 1,230 medications were identified among the patients. In 181 44.1 patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients p0.658, this rate was higher in patients aged 65 years and over p0.048 and patients with polypharmacy p0.001. Also, the interaction rates were higher in patients admitted with cerebrovascular disease p0.038 and trauma p0.002. According to the Lexicomp drug information system, potential drug-drug interactions were classified into risk category C n299, 72.9, risk category D n22, 5.4, and risk category X n9, 2.2. The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X. Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.

 Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments. Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software. Results: The median age of patients was 63 range, 19-96 years, with 55.4 n227 being female and 44.6 n183 were male. A total of 1,230 medications were identified among the patients. In 181 44.1 patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients p0.658, this rate was higher in patients aged 65 years and over p0.048 and patients with polypharmacy p0.001. Also, the interaction rates were higher in patients admitted with cerebrovascular disease p0.038 and trauma p0.002. According to the Lexicomp drug information system, potential drug-drug interactions were classified into risk category C n299, 72.9, risk category D n22, 5.4, and risk category X n9, 2.2. The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X. Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.

 Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments. Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software. Results: The median age of patients was 63 range, 19-96 years, with 55.4 n227 being female and 44.6 n183 were male. A total of 1,230 medications were identified among the patients. In 181 44.1 patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients p0.658, this rate was higher in patients aged 65 years and over p0.048 and patients with polypharmacy p0.001. Also, the interaction rates were higher in patients admitted with cerebrovascular disease p0.038 and trauma p0.002. According to the Lexicomp drug information system, potential drug-drug interactions were classified into risk category C n299, 72.9, risk category D n22, 5.4, and risk category X n9, 2.2. The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X. Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.

 Amaç: Bu çalışmanın amacı, acil servislere başvuran yetişkin hastalarda ilaç-ilaç etkileşimi potansiyelini değerlendirmektir. Gereç ve Yöntemler: Bu kesitsel çalışmaya, acil servisin kırmızı bölgesine kabul edilen, muayene edilen, tedavi edilen ve birden fazla ilaç alan 410 hasta dahil edilmiştir. İlaç-ilaç etkileşimi analizi LexiInteract yazılımı kullanılarak gerçekleştirilmiştir. Bulgular: Hastaların ortanca yaşı 63 aralık, 19-96 yıl olup 55,4ü n227 kadın ve 44,5i n183 erkektir. Hastalar arasında toplam 1.230 ilaç tespit edilmiştir. 181 44,1 hastada 330 adet olası ilaç-ilaç etkileşimi tespit edilmiştir. Erkek ve kadın hastalar arasında ilaç-ilaç etkileşimi oranları bakımından anlamlı bir fark bulunmazken p0,658, 65 yaş ve üzeri hastalarda p0,048 ve çoklu ilaç kullanımı olan hastalarda p0,001 bu oran daha yüksekti. Ayrıca, serebrovasküler hastalık p0,038 ve travma p0,002 ile başvuran hastalarda da etkileşim oranları daha yüksek idi. Lexicomp ilaç bilgi sistemine göre, olası ilaç-ilaç etkileşimleri risk kategorisi C n299, 72,9, risk kategorisi D n22, 5,4 ve risk kategorisi X n9, 2,2 olarak sınıflandırıldı. En sık etkileşime giren ilaç çiftleri, C kategorisinde Furosemid-Salbutamol, D kategorisinde Enoksaparin-Asetilsalisilik asit ve X kategorisinde Deksketoprofen-Asetilsalisilik asit idi. Sonuç: Acil servisin kırmızı bölgesinde tedavi edilen hastaların neredeyse yarısı ilaç etkileşimi riski altındaydı. Acil servis hasta bakımının kritik alanlarında tıbbi talimatlara başlamadan önce ilaç-ilaç etkileşimi riskinin değerlendirilmesi esastır ve potansiyel yan etkilerle ilgili olarak takip düzenlenmelidir.

Article Details

Drug-Drug Interactions in the Red Zone of the Emergency Department: A Retrospective Study

Authors:

Ş. Efsun Antmen | Canan Çulha | Mesut Sancar | Sema Erden Ertürk | Necmiye Canacankatan | Mehmet Canacankatan

Publisher:

Duzce University

Main Topics:

Emergency Medicine

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.228-233

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329234

pISSN:

1307-671X

Drug interaction

emergency service

red zone

clinical pharmacistİlaç etkileşimi

acil servis

kırmızı bölge

klinik eczacı

Issues

Article Details

Authors: Ş. Efsun Antmen | Canan Çulha | Mesut Sancar | Sema Erden Ertürk | Necmiye Canacankatan | Mehmet Canacankatan

Publisher: Duzce University

Main Topics: Emergency Medicine

Journal: Duzce Medical Journal Vol.26 Issue 3, pp.228-233

Document Type: Article

Publication Date: 12/2024

Document Language: English

Document ID (Org No.): 2001329234

pISSN: 1307-671X

Issues

Authors:

Ş. Efsun Antmen | Canan Çulha | Mesut Sancar | Sema Erden Ertürk | Necmiye Canacankatan | Mehmet Canacankatan

Publisher:

Duzce University

Main Topics:

Emergency Medicine

Journal:

Duzce Medical Journal Vol.26 Issue 3, pp.228-233

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001329234

pISSN:

1307-671X