Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

Cengiz Dıbekoglu; Ejder Saylav Bora; Ebru Eroğlu; Guner Yurtsever; Yiğit Uyanıkgil; Oytun Erbaş

Article Details

Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

Authors:

Cengiz Dıbekoglu | Ejder Saylav Bora | Ebru Eroğlu | Guner Yurtsever | Yiğit Uyanıkgil | Oytun Erbaş

Publisher:

Prusa Medical Publishing

Main Topics:

General Surgery

Journal:

The European Research Journal Vol.9 Issue 5, pp.1149-1156

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001288123

pISSN:

2149-3189

Keywords:

Abstract:

 Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxibs potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection FIP, followed by a one-hour administration of Celecoxib at 50 mgkgday to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers malondialdehyde MDA and pro-inflammatory cytokines Tumor Necrosis Faftor-α TNF-α. Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen PaO2 and carbon dioxide PaCO2 pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation PaO2 in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrityfurther research, including clinical trials, to validate its effectiveness and safety in human sepsis management.

 Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxibs potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection FIP, followed by a one-hour administration of Celecoxib at 50 mgkgday to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers malondialdehyde MDA and pro-inflammatory cytokines Tumor Necrosis Faftor-α TNF-α. Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen PaO2 and carbon dioxide PaCO2 pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation PaO2 in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrityfurther research, including clinical trials, to validate its effectiveness and safety in human sepsis management.

 Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxibs potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection FIP, followed by a one-hour administration of Celecoxib at 50 mgkgday to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers malondialdehyde MDA and pro-inflammatory cytokines Tumor Necrosis Faftor-α TNF-α. Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen PaO2 and carbon dioxide PaCO2 pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation PaO2 in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrityfurther research, including clinical trials, to validate its effectiveness and safety in human sepsis management.

 Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxibs potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection FIP, followed by a one-hour administration of Celecoxib at 50 mgkgday to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers malondialdehyde MDA and pro-inflammatory cytokines Tumor Necrosis Faftor-α TNF-α. Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen PaO2 and carbon dioxide PaCO2 pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation PaO2 in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrityfurther research, including clinical trials, to validate its effectiveness and safety in human sepsis management.

Article Details

Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

Authors:

Cengiz Dıbekoglu | Ejder Saylav Bora | Ebru Eroğlu | Guner Yurtsever | Yiğit Uyanıkgil | Oytun Erbaş

Publisher:

Prusa Medical Publishing

Main Topics:

General Surgery

Journal:

The European Research Journal Vol.9 Issue 5, pp.1149-1156

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001288123

pISSN:

2149-3189

Celecoxib

lung injury

sepsis

anti-inflammation

Issues

Article Details

Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats

Authors: Cengiz Dıbekoglu | Ejder Saylav Bora | Ebru Eroğlu | Guner Yurtsever | Yiğit Uyanıkgil | Oytun Erbaş

Publisher: Prusa Medical Publishing

Main Topics: General Surgery

Journal: The European Research Journal Vol.9 Issue 5, pp.1149-1156

Document Type: Article

Publication Date: 4/2023

Document Language: English

Document ID (Org No.): 2001288123

pISSN: 2149-3189

Celecoxib

lung injury

sepsis

anti-inflammation

Issues

Authors:

Cengiz Dıbekoglu | Ejder Saylav Bora | Ebru Eroğlu | Guner Yurtsever | Yiğit Uyanıkgil | Oytun Erbaş

Publisher:

Prusa Medical Publishing

Main Topics:

General Surgery

Journal:

The European Research Journal Vol.9 Issue 5, pp.1149-1156

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001288123

pISSN:

2149-3189