Synthesis of Substituted-4-chloromethylcoumarines ofAnticipated Antifungal Activity by Microwave or Infrared (IR)Irradiations

Ali Ibrahim AL-Jobrry

Article Details

Synthesis of Substituted-4-chloromethylcoumarines ofAnticipated Antifungal Activity by Microwave or Infrared (IR)Irradiations

Authors:

Ali Ibrahim AL-Jobrry

Publisher:

Tikrit University, Iraq

Journal:

Tikrit Journal of Pharmaceutical Sciences Vol.6 Issue 1, pp.50-55

Document Type:

Article

Publication Date:

1/2010

Document Language:

English

Document ID (Org No.):

2001531978

pISSN:

2664-231X

Abstract:

 Rapid and selective free radical monochlorination of the (la-d) substituted -4-methyl coumarines was achieved using sodium hypochlorite under microwave conditions to synthesize substituted-4-chloromethyl coumarines(2a-d)of anticipated antifungal activity,while irradiation using the assistance of IR lamp was failed to chlorinate these derivatives. The advantages of Microwave irradiation provide shorter reaction times, and higher yields . The structures of these compounds were confirmed by IR&uv Spectrophotometei.

Article Details

Synthesis of Substituted-4-chloromethylcoumarines ofAnticipated Antifungal Activity by Microwave or Infrared (IR)Irradiations

Authors: Ali Ibrahim AL-Jobrry

Publisher: Tikrit University, Iraq

Journal: Tikrit Journal of Pharmaceutical Sciences Vol.6 Issue 1, pp.50-55

Document Type: Article

Publication Date: 1/2010

Document Language: English

Document ID (Org No.): 2001531978

pISSN: 2664-231X

Issues

Authors:

Ali Ibrahim AL-Jobrry

Publisher:

Tikrit University, Iraq

Journal:

Tikrit Journal of Pharmaceutical Sciences Vol.6 Issue 1, pp.50-55

Document Type:

Article

Publication Date:

1/2010

Document Language:

English

Document ID (Org No.):

2001531978

pISSN:

2664-231X