Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System

Şebnem Şenol

Article Details

Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System

Authors:

Şebnem Şenol

Publisher:

Turkish Chemical Society

Main Topics:

Reaction Kinetics and Dynamics

Journal:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.12 Issue 2, pp.85-98

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001345107

pISSN:

2149-0120

Keywords:

Abstract:

 The primary purpose of this study was to investigate the effect of active pharmaceutical ingredients APIs with varying particle sizes and properties on drug release and to develop matrix-type tablets based on polyacrylic acid sodium salt PAANa with different gelatin ratios for enhanced paracetamol release. Micronized, superfine, and purified paracetamol APIs were selected as model drugs to assess the impact of these APIs on drug release. Paracetamol is a frequently used medication in healthcare, so it is crucial to select the API with the optimal release rate and an economical, environmentally friendly production method. The direct compression method was employed in the preparation of the tablets due to its simplicity and ease of integration on an industrial scale. The release studies, release kinetics, scanning electron microscope SEM, Fourier transform infrared spectroscopy FT-IR, physical properties, and microbial analyses Escherichia coli, total mold, yeast were investigated. The release studies at pH 1.2 and pH 7.4 revealed that the type of active pharmaceutical ingredient, especially micronized paracetamol API and superfine API, affects the paracetamol release ratio. Microbial analyses showed that produced tablets were convenient for health. In addition, prepared tablets with added gelatine can be used to deliver paracetamol with the desired release profile.

 The primary purpose of this study was to investigate the effect of active pharmaceutical ingredients APIs with varying particle sizes and properties on drug release and to develop matrix-type tablets based on polyacrylic acid sodium salt PAANa with different gelatin ratios for enhanced paracetamol release. Micronized, superfine, and purified paracetamol APIs were selected as model drugs to assess the impact of these APIs on drug release. Paracetamol is a frequently used medication in healthcare, so it is crucial to select the API with the optimal release rate and an economical, environmentally friendly production method. The direct compression method was employed in the preparation of the tablets due to its simplicity and ease of integration on an industrial scale. The release studies, release kinetics, scanning electron microscope SEM, Fourier transform infrared spectroscopy FT-IR, physical properties, and microbial analyses Escherichia coli, total mold, yeast were investigated. The release studies at pH 1.2 and pH 7.4 revealed that the type of active pharmaceutical ingredient, especially micronized paracetamol API and superfine API, affects the paracetamol release ratio. Microbial analyses showed that produced tablets were convenient for health. In addition, prepared tablets with added gelatine can be used to deliver paracetamol with the desired release profile.

 The primary purpose of this study was to investigate the effect of active pharmaceutical ingredients APIs with varying particle sizes and properties on drug release and to develop matrix-type tablets based on polyacrylic acid sodium salt PAANa with different gelatin ratios for enhanced paracetamol release. Micronized, superfine, and purified paracetamol APIs were selected as model drugs to assess the impact of these APIs on drug release. Paracetamol is a frequently used medication in healthcare, so it is crucial to select the API with the optimal release rate and an economical, environmentally friendly production method. The direct compression method was employed in the preparation of the tablets due to its simplicity and ease of integration on an industrial scale. The release studies, release kinetics, scanning electron microscope SEM, Fourier transform infrared spectroscopy FT-IR, physical properties, and microbial analyses Escherichia coli, total mold, yeast were investigated. The release studies at pH 1.2 and pH 7.4 revealed that the type of active pharmaceutical ingredient, especially micronized paracetamol API and superfine API, affects the paracetamol release ratio. Microbial analyses showed that produced tablets were convenient for health. In addition, prepared tablets with added gelatine can be used to deliver paracetamol with the desired release profile.

 The primary purpose of this study was to investigate the effect of active pharmaceutical ingredients APIs with varying particle sizes and properties on drug release and to develop matrix-type tablets based on polyacrylic acid sodium salt PAANa with different gelatin ratios for enhanced paracetamol release. Micronized, superfine, and purified paracetamol APIs were selected as model drugs to assess the impact of these APIs on drug release. Paracetamol is a frequently used medication in healthcare, so it is crucial to select the API with the optimal release rate and an economical, environmentally friendly production method. The direct compression method was employed in the preparation of the tablets due to its simplicity and ease of integration on an industrial scale. The release studies, release kinetics, scanning electron microscope SEM, Fourier transform infrared spectroscopy FT-IR, physical properties, and microbial analyses Escherichia coli, total mold, yeast were investigated. The release studies at pH 1.2 and pH 7.4 revealed that the type of active pharmaceutical ingredient, especially micronized paracetamol API and superfine API, affects the paracetamol release ratio. Microbial analyses showed that produced tablets were convenient for health. In addition, prepared tablets with added gelatine can be used to deliver paracetamol with the desired release profile.

Article Details

Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System

Authors:

Şebnem Şenol

Publisher:

Turkish Chemical Society

Main Topics:

Reaction Kinetics and Dynamics

Journal:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.12 Issue 2, pp.85-98

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001345107

pISSN:

2149-0120

Matrix-type tablets

Paracetamol

Release kinetics

Release properties

Antimicrobial properties.

Issues

Article Details

Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effect on the Release System

Authors: Şebnem Şenol

Publisher: Turkish Chemical Society

Main Topics: Reaction Kinetics and Dynamics

Journal: Journal of the Turkish Chemical Society Section A: Chemistry Vol.12 Issue 2, pp.85-98

Document Type: Article

Publication Date: 5/2025

Document Language: English

Document ID (Org No.): 2001345107

pISSN: 2149-0120

Matrix-type tablets

Paracetamol

Release kinetics

Release properties

Antimicrobial properties.

Issues

Authors:

Şebnem Şenol

Publisher:

Turkish Chemical Society

Main Topics:

Reaction Kinetics and Dynamics

Journal:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.12 Issue 2, pp.85-98

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001345107

pISSN:

2149-0120