Assessment of Hepatotoxic Effects of Quetiapıne  at Repeated Doses in Rats

SİNEM ILGIN; DİLEK BURUKOĞLU; MERVE BAYSAL; ÖZLEM HİNİS; ÖZLEM ATLI

doi:https://doi.org/10.18036/aubtdc.349864

Article Details

Assessment of Hepatotoxic Effects of Quetiapıne at Repeated Doses in Rats

Authors:

SİNEM ILGIN | DİLEK BURUKOĞLU | MERVE BAYSAL | ÖZLEM HİNİS | ÖZLEM ATLI

Publisher:

Eskisehir Technical University

Journal:

Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2018 Vol.7 Issue 2, pp.196-206

Document Type:

Article

Publication Date:

8/2018

Document Language:

English

Document ID (Org No.):

2000417473

pISSN:

2667-4203

DOI:

https://doi.org/10.18036/aubtdc.349864

Abstract:

 


Quetiapine
is an atypical antipsychotic drug used for treatments of patients with
schizophrenia. Although hepatotoxic effects related to quetiapine treatment
were reported in a few studies, potential hepatotoxicity of this drug was not
identified clearly. Therefore, it was aimed to evaluate possible hepatotoxic
effects of quetiapine by oral administration of this drug at 10 and 20 mg/kg
doses to rats for 30 days in our study. For this purpose, plasma aspartate
aminotransferase, alanine aminotransferase, total bilirubin and direct
bilirubin levels as markers of hepatotoxicity were determined and
histopathological examination was performed in liver tissues. According to our
results, serum aspartate aminotransferase and alanine aminotransferase levels
were significantly increased in quetiapine-administered groups, whereas total
and direct bilirubin levels were significantly increased in high dose group.
Histopathological examination of liver tissue indicated that necrotic areas
were observed in 10 mg/kg quetiapine-administered group whereas necrotic areas
were present and sinusoidal dilatation was observed in 20 mg/kg
quetiapine-administered group. According to these results, we concluded that
quetiapine may induced hepatotoxic effects in rats, dose-dependently.


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Article Details

Assessment of Hepatotoxic Effects of Quetiapıne at Repeated Doses in Rats

Authors: SİNEM ILGIN | DİLEK BURUKOĞLU | MERVE BAYSAL | ÖZLEM HİNİS | ÖZLEM ATLI

Publisher: Eskisehir Technical University

Journal: Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2018 Vol.7 Issue 2, pp.196-206

Document Type: Article

Publication Date: 8/2018

Document Language: English

Document ID (Org No.): 2000417473

pISSN: 2667-4203

DOI: https://doi.org/10.18036/aubtdc.349864

Issues

Authors:

SİNEM ILGIN | DİLEK BURUKOĞLU | MERVE BAYSAL | ÖZLEM HİNİS | ÖZLEM ATLI

Publisher:

Eskisehir Technical University

Journal:

Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2018 Vol.7 Issue 2, pp.196-206

Document Type:

Article

Publication Date:

8/2018

Document Language:

English

Document ID (Org No.):

2000417473

pISSN:

2667-4203

DOI:

https://doi.org/10.18036/aubtdc.349864