Malignant infantile osteopetrosis, presenting as hemolytic anemia: a case report

Shubhankar Mishra; Sunil Kumar Agarwalla; Bikash Ranjan Praharaj; Sushant Kumar Behera

Article Details

Malignant infantile osteopetrosis, presenting as hemolytic anemia: a case report

Authors:

Shubhankar Mishra | Sunil Kumar Agarwalla | Bikash Ranjan Praharaj | Sushant Kumar Behera

Publisher:

Eldaghayes Publisher, Tripoli, Libya

Main Topics:

Osteopetrosis | anemia | optic atrophy | hepatosplenomegaly

Journal:

International Journal of Medical Science and Public Health Vol.5 Issue 1, pp.146-146

Document Type:

Article

Publication Date:

6/2015

Document Language:

English

Document ID (Org No.):

2001521726

pISSN:

2320-4664

Keywords:

Abstract:

 The occurrence of malignant infantile osteopetrosis is observed in early stages of life along with increased sclerosis of the skeleton and decreased bone marrow spaces. The bone marrow damage of the disease leads to anemia, extramedullary hematopoiesis secondary to anemia, which result in hepatosplenomegaly, cranial nerves compression (optic nerve atrophy), and severe growth failure. The characteristic symptoms of the disease are fractures, visual damage, and bone marrow failure resulting in severe anemia. A 4-month-old infant presented with severe anemia and hepatosplenomegaly, bilateral optic atrophy, and acute respiratory tract infection. It was first thought to be hemolytic anemia or intrauterine infection. Radiological features, bone marrow studies, and clinical progression clinched the diagnosis of malignant infantile osteopetrosis. As it is a rare cause of severe anemia, clinicians should have sufficient idea about it.

Article Details

Malignant infantile osteopetrosis, presenting as hemolytic anemia: a case report

Authors: Shubhankar Mishra | Sunil Kumar Agarwalla | Bikash Ranjan Praharaj | Sushant Kumar Behera

Publisher: Eldaghayes Publisher, Tripoli, Libya

Main Topics: Osteopetrosis | anemia | optic atrophy | hepatosplenomegaly

Journal: International Journal of Medical Science and Public Health Vol.5 Issue 1, pp.146-146

Document Type: Article

Publication Date: 6/2015

Document Language: English

Document ID (Org No.): 2001521726

pISSN: 2320-4664

Osteopetrosis

anemia

optic atrophy

hepatosplenomegaly

Issues

Authors:

Shubhankar Mishra | Sunil Kumar Agarwalla | Bikash Ranjan Praharaj | Sushant Kumar Behera

Publisher:

Eldaghayes Publisher, Tripoli, Libya

Main Topics:

Osteopetrosis | anemia | optic atrophy | hepatosplenomegaly

Journal:

International Journal of Medical Science and Public Health Vol.5 Issue 1, pp.146-146

Document Type:

Article

Publication Date:

6/2015

Document Language:

English

Document ID (Org No.):

2001521726

pISSN:

2320-4664