Efficacy of Noisome as a Carrier of Locally Delivered Minocycline Hydrochloride Gel in Stage III Periodontitis : A Randomized Controlled Clinical Trial with Biochemical Analysis

Said , Israa; Ibrahim , Suzan; Ahmed , Yasmine Elsayed

Article Details

Efficacy of Noisome as a Carrier of Locally Delivered Minocycline Hydrochloride Gel in Stage III Periodontitis : A Randomized Controlled Clinical Trial with Biochemical Analysis

Authors:

Said , Israa | Ibrahim , Suzan | Ahmed , Yasmine Elsayed

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2025 Vol.40 Issue 4, pp.65-73

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

274673

Frequency:

Quarterly

pISSN:

11107642

Descriptors:

Keywords:

Abstract:

 Aim: The present trial aimed to compare the effect of noisome as a carrier of locally delivered minocycline hydrochloride gel (MHnoisome) in stage III periodontitis patients as an adjunct to non-surgical periodontal treatment as well as the releasing profile of the two gels. Materials and Methods: This research was conducted at the Faculty of Dentistry, Ain Shams University, in the Department of Oral Medicine, Periodontology, and Oral Diagnosis. It was a randomized, triple blinded, and controlled study. thirty (stage III) periodontitis patients were randomly divided (fifteen in each group) into test (MH-noisome gel + SRP) and control (MH+SRP) groups. The primary outcome was evaluating the changes in the periodontal parameters; the plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL). The secondary outcome was evaluating the releasing profile of the two gels (MH-noisome and MH). Results: After 3 months, the test and control group demonstrated a significant reduction in PI and GI but no significant difference between the two groups. There was a significant PD reduction in both groups with more significance in test group compared to the control group and significant gain in CAL in both groups with a significantly lower CAL gain in the control group. Regarding the releasing profile for the MH group the minocycline released for seven days while in MH-noisome released lasts for fourteen days. Conclusion: Noisome gel can be considered an effective therapeutic agent as an adjunct to SRP in the treatment of periodontitis. As well as increasing the time of minocycline released.

Article Details

Efficacy of Noisome as a Carrier of Locally Delivered Minocycline Hydrochloride Gel in Stage III Periodontitis : A Randomized Controlled Clinical Trial with Biochemical Analysis

Authors:

Said , Israa | Ibrahim , Suzan | Ahmed , Yasmine Elsayed

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2025 Vol.40 Issue 4, pp.65-73

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

274673

Frequency:

Quarterly

pISSN:

11107642

Descriptors:

DENTISTRY

GINGIVA

MOUTH DISEASES

INFLAMMATION

CLINICAL TESTING

Periodontitis

Minocycline hydrochloride

Noisome

Issues

Article Details

Authors: Said , Israa | Ibrahim , Suzan | Ahmed , Yasmine Elsayed

Publisher: Ain Shams University : Faculty of Dentistry

Main Topics: Medicine

Journal: Ain Shams Dental Journal 2025 Vol.40 Issue 4, pp.65-73

Document Type: Article

Publication Date: 12/2025

Document Language: English

Document ID (Org No.): 274673

Frequency: Quarterly

pISSN: 11107642

Descriptors:

Issues

Authors:

Said , Israa | Ibrahim , Suzan | Ahmed , Yasmine Elsayed

Publisher:

Ain Shams University : Faculty of Dentistry

Main Topics:

Medicine

Journal:

Ain Shams Dental Journal 2025 Vol.40 Issue 4, pp.65-73

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

274673

Frequency:

Quarterly

pISSN:

11107642