Characterization of Thermosensitive Gels for the Sustained Delivery of Dexketoprofen Trometamol for Dermal Applications

Özlem ÇULCU; Emre TUNÇEL; Sibel İLBASMIŞ TAMER; Fahriye Figen TIRNAKSIZ

Article Details

Characterization of Thermosensitive Gels for the Sustained Delivery of Dexketoprofen Trometamol for Dermal Applications

Authors:

Özlem ÇULCU | Emre TUNÇEL | Sibel İLBASMIŞ TAMER | Fahriye Figen TIRNAKSIZ

Publisher:

Gazi University

Main Topics:

Pharmacology and therapeutics

Journal:

Journal of Gazi University Health Sciences Institute 2020 Vol.2 Issue 2, pp.1-12

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2000442810

Frequency:

Monthly

pISSN:

2687-6353

Abstract:

 


In  this  report,  the  release  properties  of  dexketoprofen  (DEX)  from  propylene  glycol (PG)  and  poloxamer  gel  systems  were  investigated.  After  formulation of  gel  systems composed  of  poloxamer  338  and  PG,  rheological  experiment  was  conducted  to investigate  effects  of  PG  on  temperature-dependent  viscoelasticity  of  poloxamer  338-based gels.  It appeared  that PG and  poloxamer 338 could form gel systems  with good thermosensitive properties, the gel system containing 2.5% and 5% PG showed similar thermosensitive  properties.  In  vitro  release  studies  were  performed  at  two  different temperatures, room temperature (25  ̊C ± 0.1 ̊C) and skin temperature (32  ̊C ± 0.1 ̊C), using  Franz  diffusion  cells  and  showed  decreased  the  release  rate  of  DEX  at  skin temperature (32  ̊C) according the thermosensitive properties of poloxamer 338. Also released   amount   of   DEX   were   decreased   due   to   the   use   of   high   poloxamer concentration. At both temperatures, the highest release (39.35% at 32 °C and 31.78% at 25  ̊C in 8 hours) was obtained with 20%poloxamer + 5%PG, the lowest release (29.46% at 32 °C and 26.23% at 25  ̊C in 8 hours) was obtained with 25% poloxamer + 5% PG. After the drug releaseamount was examined, kinetic models (zero order, first order,  Higuchi,  Hixson-Crowell  and  Korsmeyer-Peppas)  were  investigated.  In  both temperatures (25  ̊C and 32  ̊C), the in vitro drug release profiles of poloxamer based formulations were fit to the Korsmeyer-Peppaskinetic model.

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Article Details

Characterization of Thermosensitive Gels for the Sustained Delivery of Dexketoprofen Trometamol for Dermal Applications

Authors: Özlem ÇULCU | Emre TUNÇEL | Sibel İLBASMIŞ TAMER | Fahriye Figen TIRNAKSIZ

Publisher: Gazi University

Main Topics: Pharmacology and therapeutics

Journal: Journal of Gazi University Health Sciences Institute 2020 Vol.2 Issue 2, pp.1-12

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 2000442810

Frequency: Monthly

pISSN: 2687-6353

Issues

Authors:

Özlem ÇULCU | Emre TUNÇEL | Sibel İLBASMIŞ TAMER | Fahriye Figen TIRNAKSIZ

Publisher:

Gazi University

Main Topics:

Pharmacology and therapeutics

Journal:

Journal of Gazi University Health Sciences Institute 2020 Vol.2 Issue 2, pp.1-12

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2000442810

Frequency:

Monthly

pISSN:

2687-6353