Effects of the online computerized cognitive training program BEYNEX on the cognitive tests of individuals with subjective cognitive impairment and Alzheimer's disease on rivastigmine therapy

Nilgün ÇINAR; Türker Ahmet Hasan ŞAHİNER

doi:https://doi.org/10.3906/sag-1905-244

Article Details

Effects of the online computerized cognitive training program BEYNEX on the cognitive tests of individuals with subjective cognitive impairment and Alzheimer's disease on rivastigmine therapy

Authors:

Nilgün ÇINAR | Türker Ahmet Hasan ŞAHİNER

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.231-238

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000749719

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1905-244

Abstract:

 

Background/aim:  Clinical  trials  conducted  on  the  efficacy  of  computerized  cognitive  training   CCT   programs  have  not  led  to  any  important  breakthroughs.  CCT  is  a  safe  and  inexpensive  approach,  but  its  efficacy  in  patients  on  rivastigmine  therapy  has  not  been  evaluated.  This  study  aims  to  compare  effects  of  CCT  and  examines  rivastigmine  to  determine  whether  CCT  has  any  further  contributions to make. Materials  and  methods:  Sixty  individuals  with  subjective  memory  complaint   SCI   and  60  individuals  with  early  stage  Alzheimer's  dementia   AD   were  subjected  to  the  Montreal  Cognitive  Assessment   MoCA ,  Cambridge  Cognition   CANTAB  tests:  MOT,  PRM,  DMS, SWM, PAL, RTI , and Bayer-ADL. After screening patients who were diagnosed with AD, we started rivastigmine patch treatment  10  cm2  =  9.5  mg .  The  SCI  and  AD  groups  were  randomly  divided,  and  one  each  of  the  SCI  and  AD  groups  were  accessed  using  BEYNEX, a web-based program. After a minimum of at least 1200 min of use, the diagnostic tests were repeated.Results: The AD groups' MoCA scores of the BEYNEX-practicing group demonstrated meaningfully increase, whereas they decreased in the control group, and the Bayer-ADL scores indicated improvement in ADL. The CANTAB tests both in SCI and AD and in groups using BEYNEX showed positive improvement in MOT, DMS, and PAL data.Conclusion: This study is a rare example that focuses on both groups with SCI and AD. The efficacy of CCT varies across cognitive domains and shows significant efficacy for AD but small improvements in cognitively healthy older adults. In future studies, integration with a smart learning algorithm may lead to interesting observations on which parameters are more sensitive to change under long-term use of CCT in a large number of subjects.

Article Details

Effects of the online computerized cognitive training program BEYNEX on the cognitive tests of individuals with subjective cognitive impairment and Alzheimer's disease on rivastigmine therapy

Authors: Nilgün ÇINAR | Türker Ahmet Hasan ŞAHİNER

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.231-238

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000749719

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1905-244

Issues

Authors:

Nilgün ÇINAR | Türker Ahmet Hasan ŞAHİNER

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.231-238

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000749719

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1905-244