Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

N.A.

Article Details

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.177-190

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001345991

pISSN:

2630-6344

Keywords:

Abstract:

 Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid AZE, and erythromycin are used alone or in combination. AZE cream 20 has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin HβC. In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose HPMC. The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream Azelderm, Orva, Türkiye. It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference f1 and similarity f2 factors.

 Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid AZE, and erythromycin are used alone or in combination. AZE cream 20 has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin HβC. In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose HPMC. The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream Azelderm, Orva, Türkiye. It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference f1 and similarity f2 factors.

 Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid AZE, and erythromycin are used alone or in combination. AZE cream 20 has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin HβC. In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose HPMC. The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream Azelderm, Orva, Türkiye. It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference f1 and similarity f2 factors.

 Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid AZE, and erythromycin are used alone or in combination. AZE cream 20 has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin HβC. In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose HPMC. The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream Azelderm, Orva, Türkiye. It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference f1 and similarity f2 factors.

Article Details

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.177-190

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001345991

pISSN:

2630-6344

Azelaic acid

acne

cyclodextrin

HPMC

hydrogel

Issues

Article Details

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmaceutical Delivery Technologies

Journal: Journal of Research in Pharmacy Vol.28 Issue 1, pp.177-190

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001345991

pISSN: 2630-6344

Azelaic acid

acne

cyclodextrin

HPMC

hydrogel

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Delivery Technologies

Journal:

Journal of Research in Pharmacy Vol.28 Issue 1, pp.177-190

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001345991

pISSN:

2630-6344