The Protection of Nebivolol Against Isoproterenol-Induced Cardiac Damage and the Role of Irisin

Merve Yılmaz Bozoğlan; Esma Şebnem Süngü; Dilan Aşkın Özek; Dilek Arslan Ateşşahin; Sermin Algül; Engin Şahna

Article Details

The Protection of Nebivolol Against Isoproterenol-Induced Cardiac Damage and the Role of Irisin

Authors:

Merve Yılmaz Bozoğlan | Esma Şebnem Süngü | Dilan Aşkın Özek | Dilek Arslan Ateşşahin | Sermin Algül | Engin Şahna

Publisher:

Harran University

Main Topics:

Tıbbi Farmakoloji | Kardiyovasküler Tıp ve Hematoloji (Diğer)

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 3, pp.527-532

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001327469

pISSN:

1304-9623

Keywords:

Abstract:

 Background: Nebivolol NEB is a β blocker that effectively relaxes the vessels while blocking adrenoreceptors. It is known that irisin dysfunction plays a role in cardiovascular diseases such as hypertension, coronary artery disease, and myocardial infarction. This study aimed to evaluate the effects of nebivolol treatment in isoproterenol ISO -induced cardiac damage on the levels of irisin, which is known to be effective in cardiomyocytes where brown fat tissue is abundant, malondialdehyde MDA, an oxidative stress indicator, and creatine kinase myocardial band CK-MB, which is released into the blood from cardiomyocytes due to myocardial damage. Materials and Methods: 28 Sprague-Dawley male rats were distributed to control, ISO, ISONEB and NEB groups. Isoproterenol 150 mgkg was given subcutaneously twice with an interval of 24 hours, and nebivolol 10 mgkgday was given via gavage for 10 days. Irisin and CK-MB were measured by ELISA, and MDA by spectrophotometric method. Results: Serum CK-MB, heart tissue MDA and serum irisin levels increased significantly with ısoproterenol induction. Nebivolol treatment significantly reduced all three parameters p0.05. Conclusions: Although further studies are needed, it is thought that irisin may play a role in ISO-induced cardiac damage and nebivolol protection.

 Background: Nebivolol NEB is a β blocker that effectively relaxes the vessels while blocking adrenoreceptors. It is known that irisin dysfunction plays a role in cardiovascular diseases such as hypertension, coronary artery disease, and myocardial infarction. This study aimed to evaluate the effects of nebivolol treatment in isoproterenol ISO -induced cardiac damage on the levels of irisin, which is known to be effective in cardiomyocytes where brown fat tissue is abundant, malondialdehyde MDA, an oxidative stress indicator, and creatine kinase myocardial band CK-MB, which is released into the blood from cardiomyocytes due to myocardial damage. Materials and Methods: 28 Sprague-Dawley male rats were distributed to control, ISO, ISONEB and NEB groups. Isoproterenol 150 mgkg was given subcutaneously twice with an interval of 24 hours, and nebivolol 10 mgkgday was given via gavage for 10 days. Irisin and CK-MB were measured by ELISA, and MDA by spectrophotometric method. Results: Serum CK-MB, heart tissue MDA and serum irisin levels increased significantly with ısoproterenol induction. Nebivolol treatment significantly reduced all three parameters p0.05. Conclusions: Although further studies are needed, it is thought that irisin may play a role in ISO-induced cardiac damage and nebivolol protection.

 Background: Nebivolol NEB is a β blocker that effectively relaxes the vessels while blocking adrenoreceptors. It is known that irisin dysfunction plays a role in cardiovascular diseases such as hypertension, coronary artery disease, and myocardial infarction. This study aimed to evaluate the effects of nebivolol treatment in isoproterenol ISO -induced cardiac damage on the levels of irisin, which is known to be effective in cardiomyocytes where brown fat tissue is abundant, malondialdehyde MDA, an oxidative stress indicator, and creatine kinase myocardial band CK-MB, which is released into the blood from cardiomyocytes due to myocardial damage. Materials and Methods: 28 Sprague-Dawley male rats were distributed to control, ISO, ISONEB and NEB groups. Isoproterenol 150 mgkg was given subcutaneously twice with an interval of 24 hours, and nebivolol 10 mgkgday was given via gavage for 10 days. Irisin and CK-MB were measured by ELISA, and MDA by spectrophotometric method. Results: Serum CK-MB, heart tissue MDA and serum irisin levels increased significantly with ısoproterenol induction. Nebivolol treatment significantly reduced all three parameters p0.05. Conclusions: Although further studies are needed, it is thought that irisin may play a role in ISO-induced cardiac damage and nebivolol protection.

 Amaç: Nebivolol NEB, adrenoreseptör blokajı yaparken beraberinde damarlarda etkin bir gev-şeme sağlayan bir β blokördür. İrisin disfonksiyonunun hipertansiyon, koroner arter hastalığı, miyokard infarktüsü gibi kardiyovasküler hastalıklarda rolü olduğu bilinmektedir. Bu çalışmada isoproterenol İSO ile indüklenmiş kardiyak hasarda nebivolol tedavisinin, kahverengi yağ doku-sunun bol bulunduğu kardiyomiyositlerde etkin olduğu bilinen irisin, oksidatif stres göstergesi malondialdehit MDA ve miyokard hasarına bağlı kardiyomiyositlerden kana salınan kreatin kinaz miyokart bandı CK-MB seviyelerine etkilerinin değerlendirilmesi amaçlanmıştır. Materyal ve metod: 28 adet Sprague-Dawley erkek sıçan kontrol, ISO, ISONEB ve NEB grupları-na dağıtıldı. İsoproterenol 150 mgkg subkutan 24 saat ara ile subkutan yolla 2 kez uygulandı, nebivolol 10 gün süreyle 10 mgkggün gavaj yoluyla verildi. İrisin ve CK-MB ELISA, MDA ise spektrofotometrik yöntem ile ölçüldü. Bulgular: Serum CK-MB, kalp dokusu MDA ve serum irisin düzeyleri İSO indüklemesi ile anlamlı arttı. Nebivolol tedavisi ise her üç parametreyi de anlamlı şekilde azalttı p0.05. Sonuç: Daha ileri çalışmalara ihtiyaç olmakla beraber, irisinin İSO indüklü kardiyak hasarda ve nebivolol koruyuculuğunda rolü olabileceği düşünülmektedir.

Article Details

The Protection of Nebivolol Against Isoproterenol-Induced Cardiac Damage and the Role of Irisin

Authors:

Merve Yılmaz Bozoğlan | Esma Şebnem Süngü | Dilan Aşkın Özek | Dilek Arslan Ateşşahin | Sermin Algül | Engin Şahna

Publisher:

Harran University

Main Topics:

Tıbbi Farmakoloji | Kardiyovasküler Tıp ve Hematoloji (Diğer)

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 3, pp.527-532

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001327469

pISSN:

1304-9623

Cardiac damage

Isoproterenol

Irisin

Nebivololardkoşullama

irisin

izoproterenol

kardiyak İR

nebivolol

Issues

Article Details

Authors: Merve Yılmaz Bozoğlan | Esma Şebnem Süngü | Dilan Aşkın Özek | Dilek Arslan Ateşşahin | Sermin Algül | Engin Şahna

Publisher: Harran University

Main Topics: Tıbbi Farmakoloji | Kardiyovasküler Tıp ve Hematoloji (Diğer)

Journal: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 3, pp.527-532

Document Type: Article

Publication Date: 12/2024

Document Language: Turkish

Document ID (Org No.): 2001327469

pISSN: 1304-9623

Issues

Authors:

Merve Yılmaz Bozoğlan | Esma Şebnem Süngü | Dilan Aşkın Özek | Dilek Arslan Ateşşahin | Sermin Algül | Engin Şahna

Publisher:

Harran University

Main Topics:

Tıbbi Farmakoloji | Kardiyovasküler Tıp ve Hematoloji (Diğer)

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 3, pp.527-532

Document Type:

Article

Publication Date:

12/2024

Document Language:

Turkish

Document ID (Org No.):

2001327469

pISSN:

1304-9623