The spectrum of underlying diseases in children with autoimmune hemolytic anemia

Alper ÖZCAN; Murat CANSEVER; Ebru YILMAZ; Ekrem ÜNAL; Musa KARAKÜKÇÜ; Türkan PATIROĞLU

doi:https://doi.org/10.32322/jhsm.985008

Article Details

The spectrum of underlying diseases in children with autoimmune hemolytic anemia

Authors:

Alper ÖZCAN | Murat CANSEVER | Ebru YILMAZ | Ekrem ÜNAL | Musa KARAKÜKÇÜ | Türkan PATIROĞLU

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences and Medicine 2021 Vol.4 Issue 6, pp.772-778

Document Type:

Article

Publication Date:

9/2021

Document Language:

English

Document ID (Org No.):

2000481789

Frequency:

Bimonthly

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.985008

Abstract:

 

Aim: Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against red blood cells. We aimed to describe the clinical presentation, hematologic and biochemical profiles, treatment modalities, underlying diseases and outcomes in children suffering from AIHA. 
Material and Method: In a retrospectively manner, we consecutively recrutied 62 children (aged 1 month-18 years) with AIHA who had been followed  in Erciyes University Child Hospital between January, 2000 and November, 2017. 
Results: The mean age at time of diagnosis was 61.9±51.9 months (range:1-192) in 62 children including 28 girls and 34 boys. The most common complaints included fatigue and fever while the most common findings were jaundice and hepatosplenomegaly. In 22 children (35.4%), there was a comorbid, active, non-specific infection (upper respiratory tract infection, lower respiratory tract infection, diarrhea, urinary tract infection). At time of diagnosis, mean hemoglobin (Hb) level was 6.9±2.5 g/dL (range: 5-9). The glucocorticoid therapy was given in majority of the patients while no medical treatment was given to 4 patients. Of the patients with primary AIHA, 6 patients were unresponsive to the treatment while one patient responded partially. It was found that there were underlying risk factors in 36 patients with secondary AIHA, as immunodeficiency and autoimmune disorders being the most common risk factors. 
Conclusion: The immunodeficiencies were highly prevalent in children included. By advance of whole exome sequencing technology, we believe that primary immunodeficiencies was the most common underlying disease in our study detected quite high in presented children.

Article Details

The spectrum of underlying diseases in children with autoimmune hemolytic anemia

Authors: Alper ÖZCAN | Murat CANSEVER | Ebru YILMAZ | Ekrem ÜNAL | Musa KARAKÜKÇÜ | Türkan PATIROĞLU

Publisher: MediHealth Academy Yayıncılık

Main Topics: Promotion of health

Journal: Journal of Health Sciences and Medicine 2021 Vol.4 Issue 6, pp.772-778

Document Type: Article

Publication Date: 9/2021

Document Language: English

Document ID (Org No.): 2000481789

Frequency: Bimonthly

eISSN: 2636-8579

DOI: https://doi.org/10.32322/jhsm.985008

Issues

Authors:

Alper ÖZCAN | Murat CANSEVER | Ebru YILMAZ | Ekrem ÜNAL | Musa KARAKÜKÇÜ | Türkan PATIROĞLU

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences and Medicine 2021 Vol.4 Issue 6, pp.772-778

Document Type:

Article

Publication Date:

9/2021

Document Language:

English

Document ID (Org No.):

2000481789

Frequency:

Bimonthly

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.985008