Preoperative hemogram-related parameters to distinguish renal cell carcinoma from benign kidney masses: HERR score

Ali Rıza TÜRKOĞLU; Yasemin ÜSTÜNDAĞ

doi:https://doi.org/10.18621/eurj.408088

Article Details

Preoperative hemogram-related parameters to distinguish renal cell carcinoma from benign kidney masses: HERR score

Authors:

Ali Rıza TÜRKOĞLU | Yasemin ÜSTÜNDAĞ

Publisher:

Prusa Medical Publishing

Main Topics:

Promotion of health

Journal:

The European Research Journal 2019 Vol.5 Issue 1, pp.42-49

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2000662928

Frequency:

Bimonthly

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.408088

Abstract:

 


Objectives: Renal cell carcinoma (RCC) accounts for approximately 90% of all kidney malignancies, and it is difficult to preoperatively distinguish between tumors and benign masses without a kidney biopsy in small renal masses. We investigated whether any preoperatively defined hemogram-related parameters had a predictive value that would distinguish RCC from benign kidney masses using a novel scoring method. 

Methods: Between January 2011 and November 2017, 330 patients diagnosed with kidney masses and who received an operation were included. Fifty-six masses were benign. The neutrophil-to-lymphocyte count (NLR), platelet-to-lymphocyte count, lymphocyte-to-monocyte count, mean platelet volume, platelet count ratio, and hemoglobin to red cell distribution width ratios were calculated. The hemogram-related parameters were combined with the tumor size to establish the hemogram-related risk (HERR) score. The area under the receiver operating characteristics curve, sensitivity, specificity, and likelihood ratios were evaluated to preoperatively diagnose RCC.

Results: Histological findings confirmed RCC in 274 patients. The NLR [median (interquartile range)] was higher in patients with RCC, 3.7 (4.7), compared to a benign kidney mass, 2.4 (2.2) (p < 0.001). A HERR score cut-off of ≥ 3 showed a good sensitivity at 78% with an LR+ of 10.8 [95% confidence interval (CI): 7.0-16.4] and an LR- of 1.2 (95% CI: 1.0-1.5). 

Conclusion: Our study, despite being a preliminary validation, is the first to evaluate hemogram-related parameters for preoperatively discriminating between RCC and benign renal masses, and the HERR score serves as a potential diagnostic biomarker for this. 



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Article Details

Preoperative hemogram-related parameters to distinguish renal cell carcinoma from benign kidney masses: HERR score

Authors: Ali Rıza TÜRKOĞLU | Yasemin ÜSTÜNDAĞ

Publisher: Prusa Medical Publishing

Main Topics: Promotion of health

Journal: The European Research Journal 2019 Vol.5 Issue 1, pp.42-49

Document Type: Article

Publication Date: 1/2019

Document Language: English

Document ID (Org No.): 2000662928

Frequency: Bimonthly

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.408088

Issues

Authors:

Ali Rıza TÜRKOĞLU | Yasemin ÜSTÜNDAĞ

Publisher:

Prusa Medical Publishing

Main Topics:

Promotion of health

Journal:

The European Research Journal 2019 Vol.5 Issue 1, pp.42-49

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2000662928

Frequency:

Bimonthly

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.408088