Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Gozde Ozcan; Fatma Tuba Akdeniz; Seda Güleç; Zerrin Barut; Deryanaz Billur; Turgay İsbir; Cumhur Kaan Yaltırık

Article Details

Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Authors:

Gozde Ozcan | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Turgay İsbir | Cumhur Kaan Yaltırık

Publisher:

Istanbul University

Main Topics:

Clinical Sciences

Journal:

Experimed Vol.13 Issue 1, pp.54-58

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001289677

pISSN:

2667-5846

Keywords:

Abstract:

 Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor EGFR as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye 34 cases, 36 controls, genotyping and statistical analyses were performed by using real-time-polymerase chain reaction RT-PCR and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes p  0.028. The CC genotype frequency was significantly greater in the control group compared to the glioma group p0.005. When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients p0.012. Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

 Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor EGFR as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye 34 cases, 36 controls, genotyping and statistical analyses were performed by using real-time-polymerase chain reaction RT-PCR and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes p  0.028. The CC genotype frequency was significantly greater in the control group compared to the glioma group p0.005. When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients p0.012. Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

 Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor EGFR as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye 34 cases, 36 controls, genotyping and statistical analyses were performed by using real-time-polymerase chain reaction RT-PCR and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes p  0.028. The CC genotype frequency was significantly greater in the control group compared to the glioma group p0.005. When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients p0.012. Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

 Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor EGFR as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye 34 cases, 36 controls, genotyping and statistical analyses were performed by using real-time-polymerase chain reaction RT-PCR and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes p  0.028. The CC genotype frequency was significantly greater in the control group compared to the glioma group p0.005. When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients p0.012. Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

Article Details

Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Authors:

Gozde Ozcan | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Turgay İsbir | Cumhur Kaan Yaltırık

Publisher:

Istanbul University

Main Topics:

Clinical Sciences

Journal:

Experimed Vol.13 Issue 1, pp.54-58

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001289677

pISSN:

2667-5846

Glioma

EGFR Gene

Variation

SNP

Issues

Article Details

Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Authors: Gozde Ozcan | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Turgay İsbir | Cumhur Kaan Yaltırık

Publisher: Istanbul University

Main Topics: Clinical Sciences

Journal: Experimed Vol.13 Issue 1, pp.54-58

Document Type: Article

Publication Date: 11/2023

Document Language: English

Document ID (Org No.): 2001289677

pISSN: 2667-5846

Glioma

EGFR Gene

Variation

SNP

Issues

Authors:

Gozde Ozcan | Fatma Tuba Akdeniz | Seda Güleç | Zerrin Barut | Deryanaz Billur | Turgay İsbir | Cumhur Kaan Yaltırık

Publisher:

Istanbul University

Main Topics:

Clinical Sciences

Journal:

Experimed Vol.13 Issue 1, pp.54-58

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001289677

pISSN:

2667-5846