Immunohistochemical Expression of Beclin1 and Lc3 in the Ovary and Oviduct during Early Pregnancy in Rats

Sema Uslu; Füsun Erhan Baycumendur; Elif Nur Taş Kepenek

Article Details

Immunohistochemical Expression of Beclin1 and Lc3 in the Ovary and Oviduct during Early Pregnancy in Rats

Authors:

Sema Uslu | Füsun Erhan Baycumendur | Elif Nur Taş Kepenek

Publisher:

Dicle University

Main Topics:

Veteriner Histoloji ve Embriyolojisi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.18 Issue 1, pp.23-27

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001341801

pISSN:

1307-9972

Keywords:

Abstract:

 Proteins associated with autophagy are called Autophagy related proteins Atg proteins. Atg6 Beclin 1 complex regulates autophagy at the molecular level and lyses cytosolic proteins, organelles and cytoplasmic components in the autophagosome during autophagy. LC3 is an autophagosomal marker. Monitoring autophagy-related processes is very important in understanding pregnancy metabolism. In this study, Beclin 1 and LC3 were immunohistochemically demonstrated in the ovary and oviduct on day 5 in the first pregnancy period. Accordingly, on the 5th day of pregnancy, it was determined that autophagy continued to increase in pregnancy with the immunohistochemical  of Beclin 1, LC3 in interstitial cells, germinative epithelium, follicle granulosa cells and theca internaexterna in the ovary and epithelial cells in the oviduct.

 Proteins associated with autophagy are called Autophagy related proteins Atg proteins. Atg6 Beclin 1 complex regulates autophagy at the molecular level and lyses cytosolic proteins, organelles and cytoplasmic components in the autophagosome during autophagy. LC3 is an autophagosomal marker. Monitoring autophagy-related processes is very important in understanding pregnancy metabolism. In this study, Beclin 1 and LC3 were immunohistochemically demonstrated in the ovary and oviduct on day 5 in the first pregnancy period. Accordingly, on the 5th day of pregnancy, it was determined that autophagy continued to increase in pregnancy with the immunohistochemical  of Beclin 1, LC3 in interstitial cells, germinative epithelium, follicle granulosa cells and theca internaexterna in the ovary and epithelial cells in the oviduct.

 Proteins associated with autophagy are called Autophagy related proteins Atg proteins. Atg6 Beclin 1 complex regulates autophagy at the molecular level and lyses cytosolic proteins, organelles and cytoplasmic components in the autophagosome during autophagy. LC3 is an autophagosomal marker. Monitoring autophagy-related processes is very important in understanding pregnancy metabolism. In this study, Beclin 1 and LC3 were immunohistochemically demonstrated in the ovary and oviduct on day 5 in the first pregnancy period. Accordingly, on the 5th day of pregnancy, it was determined that autophagy continued to increase in pregnancy with the immunohistochemical  of Beclin 1, LC3 in interstitial cells, germinative epithelium, follicle granulosa cells and theca internaexterna in the ovary and epithelial cells in the oviduct.

 Otofaji ile bağlantılı proteinler Autophagy Related Proteins, Atg proteinleri olarak isimlendirilir. Otofajinin moleküler düzeyde düzenlenmesinde Atg6 Beclin 1 kompleksi ve otofaji sırasında otofagozomda sitozolik proteinleri, organelleri, sitoplazmik bileşenleri lize eden LC3 ise otofagozomal işaretleyicilerdendir. Otofaji ile ilgili süreçlerin izlenmesi gebelik metabolizmasının anlaşılmasında oldukça önemlidir. Yapılan çalışmada gebeliğin birinci periyodu içinde 5. günde ovaryum ve oviduktta Beclin 1, LC3 immunohistokimyasal olarak gösterilmiştir. Buna göre gebeliğin 5. gününde ovaryumda intertisyel hücreler, germinatif epitelde, folikül granüloza hücrelerinde ve teka internaeksternada, oviduktta ise epitel hücrelerinde, Beclin 1, LC3ün immunohistokimyasal olarak  liği ile otofajinin gebelikte artarak devam ettiği belirlenmiştir.

Article Details

Immunohistochemical Expression of Beclin1 and Lc3 in the Ovary and Oviduct during Early Pregnancy in Rats

Authors:

Sema Uslu | Füsun Erhan Baycumendur | Elif Nur Taş Kepenek

Publisher:

Dicle University

Main Topics:

Veteriner Histoloji ve Embriyolojisi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.18 Issue 1, pp.23-27

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001341801

pISSN:

1307-9972

Autophagy

beclin 1

lc3

pregnancy

wistar albino ratBeclin 1

gebelik

lc3

otofaji

wistar albino rat

Issues

Article Details

Authors: Sema Uslu | Füsun Erhan Baycumendur | Elif Nur Taş Kepenek

Publisher: Dicle University

Main Topics: Veteriner Histoloji ve Embriyolojisi

Journal: Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.18 Issue 1, pp.23-27

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001341801

pISSN: 1307-9972

Issues

Authors:

Sema Uslu | Füsun Erhan Baycumendur | Elif Nur Taş Kepenek

Publisher:

Dicle University

Main Topics:

Veteriner Histoloji ve Embriyolojisi

Journal:

Dicle Üniversitesi Veteriner Fakültesi Dergisi Vol.18 Issue 1, pp.23-27

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001341801

pISSN:

1307-9972