Histological Effects of Different Doses of Anabolic Androgenic Steroids (Sustanon&reg;250) on Testis of Male albino Rats

Maha Haijan Ahmed; Najla Saud Al-Saud; Abdulkader Mohammed Shaikh Omar; Heba Fikry; Sabah Mahmoud Hassan

Article Details

Histological Effects of Different Doses of Anabolic Androgenic Steroids (Sustanon®250) on Testis of Male albino Rats

Authors:

Maha Haijan Ahmed | Najla Saud Al-Saud | Abdulkader Mohammed Shaikh Omar | Heba Fikry | Sabah Mahmoud Hassan

Publisher:

AENSI (American-Eurasian Network for Scientific Information)

Journal:

Australian Journal of Basic and Applied Sciences Vol.13 Issue 2, pp.72-86

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2001858001

pISSN:

1991-8178

Abstract:

 Context: The phenomenon of abusing Anabolic-androgenic steroids (AASs) by many youth and athletes is a serious health phenomenon which increase rapidly in recent years.Sustanon is one of AAS typically containing four different testosterone esters which provides persistent release of testosterone into the blood and produces a stable level for a longtime. Aims:This study was conducted to determine the effect of paternal Sustanon® 250administration on reproductive performance of male albino rats.Materials and methods: Twenty male albino rats were used in the current study; they were randomly divided into four groups. Each group contains twenty rats. Control group, which represents rats did not receive any treatment.Experimental groups II, III and IV is treated weekly with Sustanon ®250 in 50, 100 and 150 mg/kg intramuscularly weekly respectively for 16 weeks.Results: Sustanon ® 250 seems to significantly (P<0.05) increased serum level of testosterone in rats in experimental group as compared to control group. The histological results revealed severe degeneration of the seminiferous tubules with necrosis and apoptosis. Conclusion:The present work illustrated the extensive effects of toxic doses of Sustanon® 250 on testis of the rats. For this reason, drug-prevention counseling to athletes and teenagers is focused on the use of AAS. Also, physicians should be informed about the physiologic effects, and should be limited to those with a medical indication and under observation. [.

Article Details

Histological Effects of Different Doses of Anabolic Androgenic Steroids (Sustanon&reg;250) on Testis of Male albino Rats

Authors: Maha Haijan Ahmed | Najla Saud Al-Saud | Abdulkader Mohammed Shaikh Omar | Heba Fikry | Sabah Mahmoud Hassan

Publisher: AENSI (American-Eurasian Network for Scientific Information)

Journal: Australian Journal of Basic and Applied Sciences Vol.13 Issue 2, pp.72-86

Document Type: Article

Publication Date: 1/2019

Document Language: English

Document ID (Org No.): 2001858001

pISSN: 1991-8178

Issues

Histological Effects of Different Doses of Anabolic Androgenic Steroids (Sustanon®250) on Testis of Male albino Rats

Authors:

Maha Haijan Ahmed | Najla Saud Al-Saud | Abdulkader Mohammed Shaikh Omar | Heba Fikry | Sabah Mahmoud Hassan

Publisher:

AENSI (American-Eurasian Network for Scientific Information)

Journal:

Australian Journal of Basic and Applied Sciences Vol.13 Issue 2, pp.72-86

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

2001858001

pISSN:

1991-8178