Evaluation of the correlation between quantitative measurement of the foveal avascular zone and retinal vessel density and outer retinal disruptions in diabetic patients

Nagihan UĞURLU; Ayşe Güzin Taşlipinar UZEL; Ahmet ŞENGÜN; Fatma YÜLEK; Demet ÖZDAŞ; Abbas Ali TAM; Reyhan ERSOY; Bekir ÇAKIR

Article Details

Evaluation of the correlation between quantitative measurement of the foveal avascular zone and retinal vessel density and outer retinal disruptions in diabetic patients

Authors:

Nagihan UĞURLU | Ayşe Güzin Taşlipinar UZEL | Ahmet ŞENGÜN | Fatma YÜLEK | Demet ÖZDAŞ | Abbas Ali TAM | Reyhan ERSOY | Bekir ÇAKIR

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1041-1046

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000749971

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim: The  aim  of  the  current  study  was  to  evaluate  the  correlation  between  the  integrity  of  the  outer  retinal  layers  on  optical coherence tomography (OCT) and objective parameters of retinal microvascular perfusion on optical coherence tomography angiography (OCTA).Materials  and  methods:  A  total  of  105  eyes  of  54  diabetic  patients  were  included  in  the  study.  Integrity  of  the  outer  retinal  layers  including the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ) was assessed by spectral-domain optical coherence tomography. The foveal avascular zone (FAZ) area and vessel density (VD) measurements in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in all the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors were evaluated by OCTA. Associations between the quantitative measurement of the FAZ and retinal VD measurements and outer retinal disruptions were evaluated.Results: The FAZ area was correlated with outer retinal layer disruption both in the superficial plexus (r = 0.244, 0.228, 0.212, P = 0.013, 0.02, 0.031 for the ELM, EZ, and IZ, respectively) and the deep capillary plexus (r = 0.298, 0.234, 0.197, P = 0.002, 0.019, 0.048 for the ELM, EZ, and IZ, respectively). A significant relationship was also found between the VD measurements in the SCP and DCP in ETDRS sectors and the outer retinal layers disruption. Conclusion: The results of the current study show a significant relationship between the quantitative OCTA parameters and the integrity of the outer retinal layers. This finding reveals a correlation between retinal capillary nonperfusion and outer retinal disruption in eyes with diabetic retinopathy.

Article Details

Evaluation of the correlation between quantitative measurement of the foveal avascular zone and retinal vessel density and outer retinal disruptions in diabetic patients

Authors: Nagihan UĞURLU | Ayşe Güzin Taşlipinar UZEL | Ahmet ŞENGÜN | Fatma YÜLEK | Demet ÖZDAŞ | Abbas Ali TAM | Reyhan ERSOY | Bekir ÇAKIR

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1041-1046

Document Type: Article

Publication Date: 7/2019

Document Language: English

Document ID (Org No.): 2000749971

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Nagihan UĞURLU | Ayşe Güzin Taşlipinar UZEL | Ahmet ŞENGÜN | Fatma YÜLEK | Demet ÖZDAŞ | Abbas Ali TAM | Reyhan ERSOY | Bekir ÇAKIR

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1041-1046

Document Type:

Article

Publication Date:

7/2019

Document Language:

English

Document ID (Org No.):

2000749971

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144