Synthesis and Characterization of Schiff base Compounds Produced from 6-Bromo-4-Fluoro-2 Aminobenzothazol Assessment against Antibacterial Activity

Hiba I. Abdullah; Wissam M. R. Al-Joboury; Ibrahim F.O. Aljoboury; Ibtihal K. Hameed; Khalid A. Al-Badrany; Mahmod A. Abdulqader

Article Details

Synthesis and Characterization of Schiff base Compounds Produced from 6-Bromo-4-Fluoro-2 Aminobenzothazol Assessment against Antibacterial Activity

Authors:

Hiba I. Abdullah | Wissam M. R. Al-Joboury | Ibrahim F.O. Aljoboury | Ibtihal K. Hameed | Khalid A. Al-Badrany | Mahmod A. Abdulqader

Publisher:

Al-Ayen Iraqi University

Journal:

AUIQ Complementary Biological System Vol.2 Issue 1, pp.118-130

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

2001932499

pISSN:

3007-973X

Keywords:

Abstract:

 Schiff bases exhibit a wide range of biological activities, including antibacterial, antifungal, anticancer, and anti-inflammatory properties. The aim of study was to synthesized 2-amino-benzothiazole derivatives and showed their novel structure leads to potent antimicrobial activity. The Schiff base compounds derived from 6-bromo-4-fluoro-2-aminobenzothazol was prepared from the reaction of 6-bromo-4-fluoro-2-aminobenzothazol compound (W1) with potassium thiocyanate in the presence of bromine. Unsaturated Alpha-Beta (W2-6) compounds were obtained from the reaction of and aromatic benzaldehyd with para -hydroxy acetophenone in a basal medium. The interaction of alpha-beta - unsaturated compounds with 4,6-dichloro-2-aminobenzothiazole gives compounds (W7-11) 4-(1-(4,6-dichlorobenzothiazole-2-El amino) - 3-aryl) phenol. The prepared compounds have been characterized by melting points and some physical properties besides the FTIR, H-NMR spectra and quantitative analysis of elements (C.H.N.). The purity for these compounds was checked by TLC. The result showed the tested compounds (W1-8 have antibacterial activity against Gram-negative bacteria while Compounds (W9-11) showed moderate antibacterial activity against S. aureus and Proteus ssp. In conclusion used the conventional method for the preparation of different substituted 2-aminobenzothiazole derivatives and showed remarkable antibacterial activity; we need further investigation to study their mechanism of actions at the molecular level.

Article Details

Synthesis and Characterization of Schiff base Compounds Produced from 6-Bromo-4-Fluoro-2 Aminobenzothazol Assessment against Antibacterial Activity

Authors:

Hiba I. Abdullah | Wissam M. R. Al-Joboury | Ibrahim F.O. Aljoboury | Ibtihal K. Hameed | Khalid A. Al-Badrany | Mahmod A. Abdulqader

Publisher:

Al-Ayen Iraqi University

Journal:

AUIQ Complementary Biological System Vol.2 Issue 1, pp.118-130

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

2001932499

pISSN:

3007-973X

Schiff base

2-Amino benzothiazoles

Chalcone

Antibacterial

6-Bromo-4 fluoro-2-aminobenzothazol

Issues

Article Details

Synthesis and Characterization of Schiff base Compounds Produced from 6-Bromo-4-Fluoro-2 Aminobenzothazol Assessment against Antibacterial Activity

Authors: Hiba I. Abdullah | Wissam M. R. Al-Joboury | Ibrahim F.O. Aljoboury | Ibtihal K. Hameed | Khalid A. Al-Badrany | Mahmod A. Abdulqader

Publisher: Al-Ayen Iraqi University

Journal: AUIQ Complementary Biological System Vol.2 Issue 1, pp.118-130

Document Type: Article

Publication Date: 12/2025

Document Language: English

Document ID (Org No.): 2001932499

pISSN: 3007-973X

Schiff base

2-Amino benzothiazoles

Chalcone

Antibacterial

6-Bromo-4 fluoro-2-aminobenzothazol

Issues

Authors:

Hiba I. Abdullah | Wissam M. R. Al-Joboury | Ibrahim F.O. Aljoboury | Ibtihal K. Hameed | Khalid A. Al-Badrany | Mahmod A. Abdulqader

Publisher:

Al-Ayen Iraqi University

Journal:

AUIQ Complementary Biological System Vol.2 Issue 1, pp.118-130

Document Type:

Article

Publication Date:

12/2025

Document Language:

English

Document ID (Org No.):

2001932499

pISSN:

3007-973X