The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis

S. Şimşek; P. Göktaş; D. COŞKUN

Article Details

The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis

Authors:

S. Şimşek | P. Göktaş | D. COŞKUN

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 1998 Vol.11 Issue 3, pp.152-155

Document Type:

Article

Publication Date:

6/1998

Document Language:

Turkish

Document ID (Org No.):

2000546906

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

Abstract:

 


Objective: To determine the in vitro activity and place of fluoroquinolones in combination therapy of brucellosis and to compare these results with the results of doxycycline plus rifampicin combination which is the current regimen of therapy.

Method: Eight blood isolates of Brucella melitensis were used. Minimal inhibitory concentration (MIC) values of doxycycline, rifampicin, ofloxacin and ciprofloxacin were determined by agar dilution method and the effect of combination was tested by simplified checkerboard method.

Results: The MIC values for doxycycline, rifampicin, ofloxacin and ciprofloxacin were found as 1.0, 4.0, 0.5 and 1.0 pg/ml respectively. The effect of combination of ofloxacin with doxycycline or rifampicin was found to be indifferent, when combinations of ciprofloxacin with doxycycline or rifampicin and doxycycline with rifampicin were additive.

Conclusion: These results may encourage clinical use of a fluoroquinolone in the combination therapy of brucellosis.

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Article Details

The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis

Authors: S. Şimşek | P. Göktaş | D. COŞKUN

Publisher: Marmara University

Main Topics: Diseases

Journal: Marmara Medical Journal 1998 Vol.11 Issue 3, pp.152-155

Document Type: Article

Publication Date: 6/1998

Document Language: Turkish

Document ID (Org No.): 2000546906

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

Issues

Authors:

S. Şimşek | P. Göktaş | D. COŞKUN

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 1998 Vol.11 Issue 3, pp.152-155

Document Type:

Article

Publication Date:

6/1998

Document Language:

Turkish

Document ID (Org No.):

2000546906

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941