The synthesis of new oxindoles as analogs of natural product 3,3′′^\prime   -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of   G6PD and 6PGD

Sinan BAYINDIR; Adnan AYNA; Yusuf TEMEL; Mehmet ÇİFTCİ

Article Details

The synthesis of new oxindoles as analogs of natural product 3,3′′^\prime -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD

Authors:

Sinan BAYINDIR | Adnan AYNA | Yusuf TEMEL | Mehmet ÇİFTCİ

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2018 Vol.42 Issue 2, pp.332-345

Document Type:

Article

Publication Date:

3/2018

Document Language:

Turkish

Document ID (Org No.):

2000726172

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Natural and synthetic derivatives that contain an indole   core are being used in medical treatments and technological processes.   Therefore, the development of new synthetic methods for the synthesis of   indole derivatives is very popular. In this study, new oxindoles with   reaction of 4,7-dihydro-1HHH-indole (2) and isatin (4) were   synthesized as analogs of natural product 3,3′′^\prime -bis(indolyl)oxindole.   The biological properties of the compounds obtained during this study were   also studied, showing that compounds 5, 7, and 12   inhibited the activity of G6PD with an IC5050_{50} of 99 μμ\mu M, 231 μμ\mu M,   and 304 μμ\mu M respectively. The activity of rat erythrocyte 6PGD was   increased in the presence of 5 and 7 and was inhibited in   the presence of 12. As indole derivative 5 was an   activator of 6PGD and inhibitor of G6PD, it was selected for docking studies   to understand the mechanism of activation and inhibition.

Article Details

The synthesis of new oxindoles as analogs of natural product 3,3′′^\prime -bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD

Authors: Sinan BAYINDIR | Adnan AYNA | Yusuf TEMEL | Mehmet ÇİFTCİ

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2018 Vol.42 Issue 2, pp.332-345

Document Type: Article

Publication Date: 3/2018

Document Language: Turkish

Document ID (Org No.): 2000726172

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Sinan BAYINDIR | Adnan AYNA | Yusuf TEMEL | Mehmet ÇİFTCİ

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2018 Vol.42 Issue 2, pp.332-345

Document Type:

Article

Publication Date:

3/2018

Document Language:

Turkish

Document ID (Org No.):

2000726172

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527