Factors Affecting Mortality in Chronic Obstructive Lung Disease

Hatice Şahin; Hasan Kahraman

Article Details

Factors Affecting Mortality in Chronic Obstructive Lung Disease

Authors:

Hatice Şahin | Hasan Kahraman

Publisher:

Sakarya University

Main Topics:

Göğüs Hastalıkları

Journal:

Sakarya Tıp Dergisi Vol.15 Issue 1, pp.9-15

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343131

pISSN:

2146-409X

Keywords:

Abstract:

 Objective: Chronic obstructive pulmonary disease COPD is a progressive lung disease causing inflammation and airflow limitation. COPD is a major cause of death worldwide. In Türkiye, COPD represents a significant health concern, ranking as the third leading cause of mortality. This study investigates factors predicting mortality in stable COPD patients. We aim to identify factors beyond respiratory function tests that can guide prognosis in these patients. Materials and Methods: We analyzed data from 75 deceased COPD patients and 98 age-matched living patients with COPD. Pulmonary function tests and blood tests were reviewed. Statistical analysis identified potential relationships between lung function, co-morbidities, and mortality in COPD. Results: While no significant differences in demographics gender, age, smoking history, BMI were found, lung function FEV1, FVC, PEF, MEF25-75 was significantly associated with mortality in deceased patients. Deceased patients also had lower hemoglobin, hematocrit, and higher sedimentationCRP levels. Eosinophil levels were significantly higher in living patients. Multivariate logistic regression analysis revealed heart failure and lung cancer as significant factors for COPD mortality. Discussion and Conclusion: This study investigated the factors predicting mortality in COPD. Elevated inflammatory markers in stable COPD patients suggested persistent inflammation. Our findings indicate that Pulmonary Function Tests, eosinophil count, hemoglobin, hematocrit, CRP, and sedimentation rate may be valuable predictors of mortality in these patients. These markers offer advantages due to their affordability, rapid accessibility, and practicality for follow-up.

 Objective: Chronic obstructive pulmonary disease COPD is a progressive lung disease causing inflammation and airflow limitation. COPD is a major cause of death worldwide. In Türkiye, COPD represents a significant health concern, ranking as the third leading cause of mortality. This study investigates factors predicting mortality in stable COPD patients. We aim to identify factors beyond respiratory function tests that can guide prognosis in these patients. Materials and Methods: We analyzed data from 75 deceased COPD patients and 98 age-matched living patients with COPD. Pulmonary function tests and blood tests were reviewed. Statistical analysis identified potential relationships between lung function, co-morbidities, and mortality in COPD. Results: While no significant differences in demographics gender, age, smoking history, BMI were found, lung function FEV1, FVC, PEF, MEF25-75 was significantly associated with mortality in deceased patients. Deceased patients also had lower hemoglobin, hematocrit, and higher sedimentationCRP levels. Eosinophil levels were significantly higher in living patients. Multivariate logistic regression analysis revealed heart failure and lung cancer as significant factors for COPD mortality. Discussion and Conclusion: This study investigated the factors predicting mortality in COPD. Elevated inflammatory markers in stable COPD patients suggested persistent inflammation. Our findings indicate that Pulmonary Function Tests, eosinophil count, hemoglobin, hematocrit, CRP, and sedimentation rate may be valuable predictors of mortality in these patients. These markers offer advantages due to their affordability, rapid accessibility, and practicality for follow-up.

 Objective: Chronic obstructive pulmonary disease COPD is a progressive lung disease causing inflammation and airflow limitation. COPD is a major cause of death worldwide. In Türkiye, COPD represents a significant health concern, ranking as the third leading cause of mortality. This study investigates factors predicting mortality in stable COPD patients. We aim to identify factors beyond respiratory function tests that can guide prognosis in these patients. Materials and Methods: We analyzed data from 75 deceased COPD patients and 98 age-matched living patients with COPD. Pulmonary function tests and blood tests were reviewed. Statistical analysis identified potential relationships between lung function, co-morbidities, and mortality in COPD. Results: While no significant differences in demographics gender, age, smoking history, BMI were found, lung function FEV1, FVC, PEF, MEF25-75 was significantly associated with mortality in deceased patients. Deceased patients also had lower hemoglobin, hematocrit, and higher sedimentationCRP levels. Eosinophil levels were significantly higher in living patients. Multivariate logistic regression analysis revealed heart failure and lung cancer as significant factors for COPD mortality. Discussion and Conclusion: This study investigated the factors predicting mortality in COPD. Elevated inflammatory markers in stable COPD patients suggested persistent inflammation. Our findings indicate that Pulmonary Function Tests, eosinophil count, hemoglobin, hematocrit, CRP, and sedimentation rate may be valuable predictors of mortality in these patients. These markers offer advantages due to their affordability, rapid accessibility, and practicality for follow-up.

 Amaç: Kronik obstrüktif akciğer hastalığı KOAH, inflamasyona ve hava akımı kısıtlılığına neden olan ilerleyici bir akciğer hastalığıdır. KOAH dünya çapında önemli bir ölüm nedenidir. Türkiyede KOAH önemli bir sağlık sorunudur ve ölüm nedenleri arasında üçüncü sırada yer almaktadır. Bu çalışma stabil KOAH hastalarında mortaliteyi öngören faktörleri araştırmaktadır. Gereç ve Yöntem: Ölen 75 KOAH hastası ve benzer özellikte 98 KOAH hastasının verileri retrospektif olarak analiz edildi. Solunum fonksiyon testleri ve kan testleri gözden geçirildi. İstatistiksel analiz, KOAHta akciğer fonksiyonu, eşlik eden hastalıklar ve mortalite arasındaki potansiyel ilişkileri tanımladı. Bulgular: Ölen hastalarda demografik özelliklerde cinsiyet, yaş, sigara içme öyküsü, BMI anlamlı bir farklılık bulunmazken, akciğer fonksiyonu FEV1, FVC, PEF, MEF25-75 ölen hastalarda mortalite ile anlamlı düzeyde ilişkiliydi. Ölen hastalarda aynı zamanda hemoglobin ve hematokrit daha düşük olarak bulunurken, sedimantasyonCRP seviyeleri ise daha yüksekti. Yaşayan hastalarda eozinofil düzeyleri anlamlı derecede yüksek olarak saptandı. Çok değişkenli analiz, kalp yetmezliği ve akciğer kanserinin KOAH mortalitesi için önemli faktörler olduğunu ortaya çıkardı. Tartışma ve Sonuç: Bu çalışmada KOAHta mortaliteyi öngören faktörler araştırıldı. Stabil KOAH hastalarında yüksek inflamatuar belirteçler kalıcı inflamasyonu düşündürmektedir. Bulgularımız Solunum Fonksiyon Testleri, eozinofil sayısı, hemoglobin, hematokrit, CRP ve sedimantasyon hızının bu hastalarda mortalitenin değerli belirleyicileri olabileceğini göstermektedir. Bu belirteçler ekonomik olmaları, hızlı ulaşılabilir olmaları ve takip açısından pratik olmaları nedeniyle avantajlar sunmaktadır.

Article Details

Factors Affecting Mortality in Chronic Obstructive Lung Disease

Authors:

Hatice Şahin | Hasan Kahraman

Publisher:

Sakarya University

Main Topics:

Göğüs Hastalıkları

Journal:

Sakarya Tıp Dergisi Vol.15 Issue 1, pp.9-15

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343131

pISSN:

2146-409X

Chronic Obstructive Pulmonary Disease

Mortality

Pulmonary Function TestKronik Obstrüktif Akciğer Hastalığı

Mortalite

Solunum Fonksiyon Testi

Issues

Article Details

Factors Affecting Mortality in Chronic Obstructive Lung Disease

Authors: Hatice Şahin | Hasan Kahraman

Publisher: Sakarya University

Main Topics: Göğüs Hastalıkları

Journal: Sakarya Tıp Dergisi Vol.15 Issue 1, pp.9-15

Document Type: Article

Publication Date: 3/2025

Document Language: English

Document ID (Org No.): 2001343131

pISSN: 2146-409X

Chronic Obstructive Pulmonary Disease

Mortality

Pulmonary Function TestKronik Obstrüktif Akciğer Hastalığı

Mortalite

Solunum Fonksiyon Testi

Issues

Authors:

Hatice Şahin | Hasan Kahraman

Publisher:

Sakarya University

Main Topics:

Göğüs Hastalıkları

Journal:

Sakarya Tıp Dergisi Vol.15 Issue 1, pp.9-15

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343131

pISSN:

2146-409X