Intravenous Infusion of Lidocaine During Anesthesia Decreases Duration of Post  Appendectomy Ileus and Systemic Analgesic Consumption

Rahman ABBASIVASH; Aidin ZEINALY; Rahim MAHMODLOU; Farshid AHMADI; Elnaz HASANZADEH; Mohammad Bagher ZEINALY; Peyman MIKAILI

Article Details

Intravenous Infusion of Lidocaine During Anesthesia Decreases Duration of Post Appendectomy Ileus and Systemic Analgesic Consumption

Authors:

Rahman ABBASIVASH | Aidin ZEINALY | Rahim MAHMODLOU | Farshid AHMADI | Elnaz HASANZADEH | Mohammad Bagher ZEINALY | Peyman MIKAILI

Publisher:

Nobel Bilim ve Araştırma Merkezi Limited

Journal:

Journal of Applied Biological Sciences 2012 Vol.6 Issue 2, pp.27-30

Document Type:

Article

Publication Date:

6/2012

Document Language:

Turkish

Document ID (Org No.):

2000831493

Frequency:

Tri-annual

eISSN:

2146-0108

Abstract:

 

Background and Aim: Animal and human studies showed that intravenous infusion of lidocaine may have beneficial effects on reducing pain
 and faster recovery of bowel movements during postoperative period. The present study aimed to investigate the effect of lidocaine infusion on
 ileus after appendectomy.
 Methods: In this randomized double-blinded clinical trial, 40 patients undergoing appendectomy enrolled in the study. The regiment of
 anesthesia was similar in both groups. The lidocaine group received 1.5 mg/kg bolus dose injection of lidocaine immediately before induction of
 anesthesia and after endotracheal intubation infusion of lidocaine started with the rate of 3 mg/min (in patients weighing less than 70 kg, with 2 mg/
 min). Infusion of lidocaine was continued during surgery and 60 minutes after it. The control group received normal saline using the same method
 and dosage as a placebo. After the surgery, up to 3 days, a blind observer recorded the patient’s systemic analgesic consumption and the time of first
 experienced passage of intestinal flatus.
 Results: Average of age, duration of anesthesia and gender distribution in both groups showed no significant difference (p>0.05). Average
 elapsed time from the end of operation to the first passage of flatus in the study group and the control group were 31.64±5.49 and 41.31±9.89 hrs,
 respectively (p<0.0001). The mean postoperative analgesic consumption (pentazocine) on the first day after operation in study and control group
 were 18±6.15 and 27.75±5.49 mg, respectively (p<0.0001). On the second day after surgery, 23 patients who had received analgesics, 5 individuals
 were in the study group and 18 individuals were in the control group (p=0.00007).
 Conclusions: The results of this study showed that lidocaine infusion during anesthesia and up to 1 hour after appendectomy reduces the
 duration of ileus and the need for systemic analgesic postoperatively.

Article Details

Intravenous Infusion of Lidocaine During Anesthesia Decreases Duration of Post Appendectomy Ileus and Systemic Analgesic Consumption

Authors: Rahman ABBASIVASH | Aidin ZEINALY | Rahim MAHMODLOU | Farshid AHMADI | Elnaz HASANZADEH | Mohammad Bagher ZEINALY | Peyman MIKAILI

Publisher: Nobel Bilim ve Araştırma Merkezi Limited

Journal: Journal of Applied Biological Sciences 2012 Vol.6 Issue 2, pp.27-30

Document Type: Article

Publication Date: 6/2012

Document Language: Turkish

Document ID (Org No.): 2000831493

Frequency: Tri-annual

eISSN: 2146-0108

Issues

Authors:

Rahman ABBASIVASH | Aidin ZEINALY | Rahim MAHMODLOU | Farshid AHMADI | Elnaz HASANZADEH | Mohammad Bagher ZEINALY | Peyman MIKAILI

Publisher:

Nobel Bilim ve Araştırma Merkezi Limited

Journal:

Journal of Applied Biological Sciences 2012 Vol.6 Issue 2, pp.27-30

Document Type:

Article

Publication Date:

6/2012

Document Language:

Turkish

Document ID (Org No.):

2000831493

Frequency:

Tri-annual

eISSN:

2146-0108