Design and development of melt solidification of meloxicam for enhancement of solubility and dissolution

N.A.

Article Details

Design and development of melt solidification of meloxicam for enhancement of solubility and dissolution

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.56-70

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346752

pISSN:

2630-6344

Keywords:

Abstract:

 The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam MLX to improve its solubility and dissolution by using the melt solidification techniques. About 40 of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer soluplus. The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer pH 6.8. The fourier transform infraredFTIR spectrophotometry, X-ray diffraction microscopyXDM and Differential scanning calorimetryDSC studies were conducted to evaluated pure drug and optimized batchMS7. Saturation solubility and  drug release showed the improve solubility and dissolution, results suggest that optimized batch MS7 containing drug and polymer in proportion of 1:4 MLX:soluplus was a successful enhancing the solubility and dissolution of MLX. The  crystallinity of MLX in amorphous sample was 18.60, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch MS7 was zero order model, showing the drug release 96.83 and R2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique.

 The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam MLX to improve its solubility and dissolution by using the melt solidification techniques. About 40 of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer soluplus. The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer pH 6.8. The fourier transform infraredFTIR spectrophotometry, X-ray diffraction microscopyXDM and Differential scanning calorimetryDSC studies were conducted to evaluated pure drug and optimized batchMS7. Saturation solubility and  drug release showed the improve solubility and dissolution, results suggest that optimized batch MS7 containing drug and polymer in proportion of 1:4 MLX:soluplus was a successful enhancing the solubility and dissolution of MLX. The  crystallinity of MLX in amorphous sample was 18.60, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch MS7 was zero order model, showing the drug release 96.83 and R2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique.

 The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam MLX to improve its solubility and dissolution by using the melt solidification techniques. About 40 of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer soluplus. The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer pH 6.8. The fourier transform infraredFTIR spectrophotometry, X-ray diffraction microscopyXDM and Differential scanning calorimetryDSC studies were conducted to evaluated pure drug and optimized batchMS7. Saturation solubility and  drug release showed the improve solubility and dissolution, results suggest that optimized batch MS7 containing drug and polymer in proportion of 1:4 MLX:soluplus was a successful enhancing the solubility and dissolution of MLX. The  crystallinity of MLX in amorphous sample was 18.60, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch MS7 was zero order model, showing the drug release 96.83 and R2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique.

 The objective of the present study was to prepare an amorphous system of BCS Class 2 drug meloxicam MLX to improve its solubility and dissolution by using the melt solidification techniques. About 40 of new chemical entities do not reach to market due to its poor aqueous solubility. Melt solidification technique is an important process to control the transition from liquid in to solid phase to obtain product in an amorphous form. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing gets converted to amorphous solid form appearing as that of glass, which improve dissolution and bioavailability of drugs. Physical mixtures of MLX were prepared by melt solidification technique using polymer soluplus. The solubility and dissolution studies for the meloxicam and batches were conducted in a phosphate buffer pH 6.8. The fourier transform infraredFTIR spectrophotometry, X-ray diffraction microscopyXDM and Differential scanning calorimetryDSC studies were conducted to evaluated pure drug and optimized batchMS7. Saturation solubility and  drug release showed the improve solubility and dissolution, results suggest that optimized batch MS7 containing drug and polymer in proportion of 1:4 MLX:soluplus was a successful enhancing the solubility and dissolution of MLX. The  crystallinity of MLX in amorphous sample was 18.60, which indicates significant decrease in crystallinity of MLX in an amorphous system. The best fit model of optimized batch MS7 was zero order model, showing the drug release 96.83 and R2 0.9904. The present investigation, successfully enhancement solubility and dissolution of MLX by using melt solidification technique.

Article Details

Design and development of melt solidification of meloxicam for enhancement of solubility and dissolution

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.56-70

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346752

pISSN:

2630-6344

Meloxicam

melt solidification

dissolution

solubility

soluplus

Issues

Article Details

Design and development of melt solidification of meloxicam for enhancement of solubility and dissolution

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.24 Issue 1, pp.56-70

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346752

pISSN: 2630-6344

Meloxicam

melt solidification

dissolution

solubility

soluplus

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.56-70

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346752

pISSN:

2630-6344