Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Saber Chebouki; Zeynep Nil Ünal; Kemal Koray Bal; Harun Gür; Onur İsmi; Murat Ünal

Article Details

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Authors:

Saber Chebouki | Zeynep Nil Ünal | Kemal Koray Bal | Harun Gür | Onur İsmi | Murat Ünal

Publisher:

Istanbul University

Main Topics:

Otorhinolaryngology

Journal:

The Turkish Journal of Ear Nose and Throat Vol.34 Issue 1, pp.1-7

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001319173

pISSN:

2602-4837

Keywords:

Abstract:

 Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor VDR is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer. Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study. Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups. Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group heshe is in, and VDR gene polymorphism can be used as a biomarker.

 Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor VDR is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer. Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study. Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups. Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group heshe is in, and VDR gene polymorphism can be used as a biomarker.

 Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor VDR is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer. Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study. Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups. Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group heshe is in, and VDR gene polymorphism can be used as a biomarker.

 Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor VDR is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer. Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study. Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups. Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group heshe is in, and VDR gene polymorphism can be used as a biomarker.

Article Details

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Authors:

Saber Chebouki | Zeynep Nil Ünal | Kemal Koray Bal | Harun Gür | Onur İsmi | Murat Ünal

Publisher:

Istanbul University

Main Topics:

Otorhinolaryngology

Journal:

The Turkish Journal of Ear Nose and Throat Vol.34 Issue 1, pp.1-7

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001319173

pISSN:

2602-4837

Vitamin D

genes

neoplasms

calcium

phosphorus

real-time polymerase chain reaction

Issues

Article Details

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Authors: Saber Chebouki | Zeynep Nil Ünal | Kemal Koray Bal | Harun Gür | Onur İsmi | Murat Ünal

Publisher: Istanbul University

Main Topics: Otorhinolaryngology

Journal: The Turkish Journal of Ear Nose and Throat Vol.34 Issue 1, pp.1-7

Document Type: Article

Publication Date: 3/2024

Document Language: English

Document ID (Org No.): 2001319173

pISSN: 2602-4837

Vitamin D

genes

neoplasms

calcium

phosphorus

real-time polymerase chain reaction

Issues

Authors:

Saber Chebouki | Zeynep Nil Ünal | Kemal Koray Bal | Harun Gür | Onur İsmi | Murat Ünal

Publisher:

Istanbul University

Main Topics:

Otorhinolaryngology

Journal:

The Turkish Journal of Ear Nose and Throat Vol.34 Issue 1, pp.1-7

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001319173

pISSN:

2602-4837