Prognostic Factors in Pediatric Classical Hodgkin Lymphoma: Concepts, Questions and Perspectives

MÃƒ¡rio BARROS; Adriana MORAIS; Vera MORAIS; Rocio HASSAN; Maria Tereza MUNIZ

Article Details

Prognostic Factors in Pediatric Classical Hodgkin Lymphoma: Concepts, Questions and Perspectives

Authors:

MÃƒ¡rio BARROS | Adriana MORAIS | Vera MORAIS | Rocio HASSAN | Maria Tereza MUNIZ

Publisher:

Bilal YILDIZ

Journal:

Journal of Pediatric Sciences 2010 Vol.2 Issue 3

Document Type:

Article

Publication Date:

6/2010

Document Language:

English

Document ID (Org No.):

2000743675

Frequency:

Bi-Annual

eISSN:

1309-1247

Abstract:

 

Hodgkin´s Lymphoma (HL) is a disease typically affecting children and young adults, with more than 80% of patients being cured. The other side of high cure rate is that a fraction of patients will receive excessive antineoplastic radiochemotherapy resulting in the well-recognized late effects of HL treatment. Current clinical and radiological characteristics used for risk stratification in most treatment centers lead to mistaken stratification in almost one third of patients. Prognostic factors in HL are, mostly, crude direct measures of tumor burden and activity (stage, number of involved lymph nodes, bulky disease, B symptoms) or indirect surrogate measures of tumor burden and activity based on laboratory parameters (hemoglobin, s-albumin levels). Clinical characteristics at presentation, as well as protein immunoexpression and Epstein-Barr virus (EBV) association, have also been identified as prognostic factors in several studies. However, when sufficiently intensive treatment for advanced stages is employed, adverse prognostic factors tend to disappear. Thus, the identification of clinical and biological factors that allow discrimination of patients who may undergo a reduction in treatment intensity is a current goal to reduce late effects in HL.

Article Details

Prognostic Factors in Pediatric Classical Hodgkin Lymphoma: Concepts, Questions and Perspectives

Authors: MÃƒ¡rio BARROS | Adriana MORAIS | Vera MORAIS | Rocio HASSAN | Maria Tereza MUNIZ

Publisher: Bilal YILDIZ

Journal: Journal of Pediatric Sciences 2010 Vol.2 Issue 3

Document Type: Article

Publication Date: 6/2010

Document Language: English

Document ID (Org No.): 2000743675

Frequency: Bi-Annual

eISSN: 1309-1247

Issues

Authors:

MÃƒ¡rio BARROS | Adriana MORAIS | Vera MORAIS | Rocio HASSAN | Maria Tereza MUNIZ

Publisher:

Bilal YILDIZ

Journal:

Journal of Pediatric Sciences 2010 Vol.2 Issue 3

Document Type:

Article

Publication Date:

6/2010

Document Language:

English

Document ID (Org No.):

2000743675

Frequency:

Bi-Annual

eISSN:

1309-1247