Diagnostic Value of Mean Platelet Volume and Platelet Distrubition Width for Massive Pulmonary Embolism in Emergency Care

Didem Oğuz

Article Details

Diagnostic Value of Mean Platelet Volume and Platelet Distrubition Width for Massive Pulmonary Embolism in Emergency Care

Authors:

Didem Oğuz

Publisher:

Ankara University

Main Topics:

Cardiology

Journal:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.550-555

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001349880

pISSN:

0365-8104

Keywords:

Abstract:

 Objectives: Massive pulmonary embolism is a life-threatening condition mostly seen in the emergency setting. Early diagnosis and treatment decrease the risk of mortality. Apart from imaging tests, increased blood levels of several parameters were shown to be helpful to identify these patients. We aimed to determine the diagnostic value of mean platelet volume and platelet distribution width for the diagnosis of acute massive pulmonary embolism. Materials and Methods: We retrospectively reviewed the medical records of patients who were admitted to the emergency department from January 2012 to January 2016. Patients who had a diagnosis of massive pulmonary embolism confirmed by computed tomography pulmonary angiography were included. Blood samples were drawn at admission. Transthoracic echocardiography was performed to evaluate right ventricular size and function. Age and sex matched patients who were admitted to the emergency department with any diagnosis other than pulmonary embolism were enrolled as a control group. Results: Eighty patients met the inclusion criteria and age and sex matched 80 patients were enrolled as a control group. The mean platelet volume and platelet distribution width were significantly higher in patients with massive pulmonary embolism compared to control group 10.10.1 fL vs 7.90.1 fL p0.001, 17 15.5-18.8 vs 13.6 12.3-15.9 p0.001 respectively. Platelet distribution width had the most powerful diagnostic value among other parameters including the mean platelet volume, D dimer and pro-BNP area under the curve0.998, p0.001. Conclusion: Massive pulmonary embolism is a thromboembolic disease associated with high mortality. Platelet distribution width and mean platelet volume are simple parameters of complete blood count that can be used to increase predictive value of previously validated tests when used concomitantly. They may also help to select patients who will undergo imaging.

 Objectives: Massive pulmonary embolism is a life-threatening condition mostly seen in the emergency setting. Early diagnosis and treatment decrease the risk of mortality. Apart from imaging tests, increased blood levels of several parameters were shown to be helpful to identify these patients. We aimed to determine the diagnostic value of mean platelet volume and platelet distribution width for the diagnosis of acute massive pulmonary embolism. Materials and Methods: We retrospectively reviewed the medical records of patients who were admitted to the emergency department from January 2012 to January 2016. Patients who had a diagnosis of massive pulmonary embolism confirmed by computed tomography pulmonary angiography were included. Blood samples were drawn at admission. Transthoracic echocardiography was performed to evaluate right ventricular size and function. Age and sex matched patients who were admitted to the emergency department with any diagnosis other than pulmonary embolism were enrolled as a control group. Results: Eighty patients met the inclusion criteria and age and sex matched 80 patients were enrolled as a control group. The mean platelet volume and platelet distribution width were significantly higher in patients with massive pulmonary embolism compared to control group 10.10.1 fL vs 7.90.1 fL p0.001, 17 15.5-18.8 vs 13.6 12.3-15.9 p0.001 respectively. Platelet distribution width had the most powerful diagnostic value among other parameters including the mean platelet volume, D dimer and pro-BNP area under the curve0.998, p0.001. Conclusion: Massive pulmonary embolism is a thromboembolic disease associated with high mortality. Platelet distribution width and mean platelet volume are simple parameters of complete blood count that can be used to increase predictive value of previously validated tests when used concomitantly. They may also help to select patients who will undergo imaging.

 Objectives: Massive pulmonary embolism is a life-threatening condition mostly seen in the emergency setting. Early diagnosis and treatment decrease the risk of mortality. Apart from imaging tests, increased blood levels of several parameters were shown to be helpful to identify these patients. We aimed to determine the diagnostic value of mean platelet volume and platelet distribution width for the diagnosis of acute massive pulmonary embolism. Materials and Methods: We retrospectively reviewed the medical records of patients who were admitted to the emergency department from January 2012 to January 2016. Patients who had a diagnosis of massive pulmonary embolism confirmed by computed tomography pulmonary angiography were included. Blood samples were drawn at admission. Transthoracic echocardiography was performed to evaluate right ventricular size and function. Age and sex matched patients who were admitted to the emergency department with any diagnosis other than pulmonary embolism were enrolled as a control group. Results: Eighty patients met the inclusion criteria and age and sex matched 80 patients were enrolled as a control group. The mean platelet volume and platelet distribution width were significantly higher in patients with massive pulmonary embolism compared to control group 10.10.1 fL vs 7.90.1 fL p0.001, 17 15.5-18.8 vs 13.6 12.3-15.9 p0.001 respectively. Platelet distribution width had the most powerful diagnostic value among other parameters including the mean platelet volume, D dimer and pro-BNP area under the curve0.998, p0.001. Conclusion: Massive pulmonary embolism is a thromboembolic disease associated with high mortality. Platelet distribution width and mean platelet volume are simple parameters of complete blood count that can be used to increase predictive value of previously validated tests when used concomitantly. They may also help to select patients who will undergo imaging.

 Amaç: Masif pulmoner emboli çoğunlukla acil serviste karşılaşılan hayatı tehdit eden bir durumdur. Erken tanı ve tedavi ölüm riskini azaltır. Görüntüleme tetkikleri dışında artmış kan seviyesindeki bazı birkaç parametrenin bu hastaları ayırt etmede yardımcı olduğu gösterilmiştir. Biz çalışmamızda, masif pulmoner emboli tanısında trombosit dağılım genişliği ve ortalama trombosit hacminin tanısal değerini tespit etmeyi amaçladık. Gereç ve Yöntem: Ocak 2012 ile Ocak 2016 yılları arasında acil servise başvuran hastaların kayıtları geriye dönük olarak incelendi. Bilgisayarlı tomografi pulmoner anjiyografi ile tanısı doğrulanmış masif pulmoner emboli hastaları çalışmaya dahil edildi. Tam kan sayımı, D-dimer, pro-BNP ve troponin I testleri için kan örnekleri ilk başvuruda alındı. Sağ ventrikül boyutu ve fonksiyonunun değerlendirilmesi için hastalara ekokardiyografi yapıldı. Yaş ve cinsiyet eşleşmesi yöntemi ile kontrol grubu çalışmaya alındı. Bulgular: Toplam 80 hasta çalışma kriterlerine uydu ve bu hastalarla yaş ve cinsiyet olarak eşleşmiş 80 kontrol hastası ayrıca çalışmaya dahil edildi. Ortalama trombosit hacmi ve trombosit dağılım genişliği anlamlı olarak masif pulmoner emboli tanısı almış hastalarda kontrol grubuna göre yüksek bulundu 10,10,1 fL, 7,90,1 fL p0,001, 17 15,5-18,8 13,6 12,3-15,9 p0,001 sırasıyla. Trombosit dağılım genişliğinin ortalama trombosit hacmi, D-dimer, pro-BNP dahil parametreler içerisinde en güçlü tanısal değere sahip olduğu tespit edildi eğri altında kalan alan0,998, p0,001. Sonuç: Masif pulmoner emboli, yüksek ölüm riski ile ilişkili bir tromboembolik hastalıktır. Trombosit dağılım genişliği ve ortalama trombosit hacmi, tam kan sayımının basit bir parçası olup daha önceden geçerliliği kabul edilmiş testlerle beraber kullanıldığında onların tanı koydurucu gücünü artırır. Görüntüleme testine gidecek hastaları tespit etmeye yardımcı olabilir.

Article Details

Diagnostic Value of Mean Platelet Volume and Platelet Distrubition Width for Massive Pulmonary Embolism in Emergency Care

Authors:

Didem Oğuz

Publisher:

Ankara University

Main Topics:

Cardiology

Journal:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.550-555

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001349880

pISSN:

0365-8104

Massive Pulmonary Embolism

Platelet Distribution Width

Mean Platelet VolumeMasif Pulmoner Emboli

Trombosit Dağılım Genişliği

Ortalama Trombosit Hacmi

Issues

Article Details

Diagnostic Value of Mean Platelet Volume and Platelet Distrubition Width for Massive Pulmonary Embolism in Emergency Care

Authors: Didem Oğuz

Publisher: Ankara University

Main Topics: Cardiology

Journal: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.550-555

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001349880

pISSN: 0365-8104

Massive Pulmonary Embolism

Platelet Distribution Width

Mean Platelet VolumeMasif Pulmoner Emboli

Trombosit Dağılım Genişliği

Ortalama Trombosit Hacmi

Issues

Authors:

Didem Oğuz

Publisher:

Ankara University

Main Topics:

Cardiology

Journal:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.75 Issue 4, pp.550-555

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001349880

pISSN:

0365-8104