Granulocytic Sarcoma Following Acute Myelogenous Leukemia Type FAB-M5 Associated with t(6;12) Involving a Rearrangement of the ETV6 Locus

Hebah M. El-Rayess; Marwan M. Refaat; Karim Saab; Nadim El-Jamal; Bimalangshu R. Dey

doi:10.12816/0035673

Article Details

Granulocytic Sarcoma Following Acute Myelogenous Leukemia Type FAB-M5 Associated with t(6;12) Involving a Rearrangement of the ETV6 Locus

Authors:

Hebah M. El-Rayess | Marwan M. Refaat | Karim Saab | Nadim El-Jamal | Bimalangshu R. Dey

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2017 Vol.65 Issue 1, pp.55-57

Document Type:

Article

Publication Date:

3/2017

Document Language:

English

Document ID (Org No.):

99976

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0035673

Descriptors:

Keywords:

Abstract:

 • Background : Acute myelogenous leukemia isa cancer that affects myeloid cells. Several complicationsoccur due to acute myelogenous leukemia of which is granulocyticsarcoma. This case report discusses the analysis ofskin abnormalities in an acute myelogenous leukemia patient.Case description : Skin examination and fine needle aspirationof the nodules in comparison with previous bone marrowbiopsy confirmed the diagnosis of myeloid sarcoma. Cytogeneticanalysis showed t(6;12) involving a rearrangement ofthe ETV6 locus. Conclusions : This is a unique report of acase of granulocytic sarcoma following acute myelogenousleukemia type 5 with t(6;12) involving a rearrangement of theETV6 locus. Several precautions should be made in diagnosingsuch conditions. A combination of systemic chemotherapyand local electron-beam therapy or PUVA to treat chemotherapyresistant leukemia cutis lesions is needed.

 • Contexte : La leucémie myéloïde aiguë est uncancer qui affecte les cellules myéloïdes. Beaucoup de complicationssont dues à cette condition, dont le sarcome granulocytaire.Dans le présent rapport les anomalies cutanéeschez une patiente atteinte d’une leucémie myéloïde aigüesont analysées. Description du cas : Un examen de la peauet une cytoponction des nodules comparée aux résultatsd’une biopsie antérieure de la moelle osseuse confirment lediagnostic d’un sarcome granulocytaire. Une analyse cytogénétiquerévèle la présence de t(6;12) impliquant un réarrangementdu locus ETV6. Conclusions : C’est l’uniquecas de sarcome granulocytaire dû à une leucémie myéloïdetype 5 avec t(6;12) impliquant un réarrangement du locusETV6 rapporté dans la littérature. Il faut prendre plusieursprécautions pour établir ce diagnostic. Une combinaison dechimiothérapie systémique et thérapie de faisceau d’électronsou PUVA pour traiter les lésions de leucémie cutanéerésistantes à la chimiothérapie est nécessaire.

Article Details

Granulocytic Sarcoma Following Acute Myelogenous Leukemia Type FAB-M5 Associated with t(6;12) Involving a Rearrangement of the ETV6 Locus

Authors:

Hebah M. El-Rayess | Marwan M. Refaat | Karim Saab | Nadim El-Jamal | Bimalangshu R. Dey

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2017 Vol.65 Issue 1, pp.55-57

Document Type:

Article

Publication Date:

3/2017

Document Language:

English

Document ID (Org No.):

99976

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0035673

Descriptors:

MEDICAL SCIENCES

ACUTE LYMPHOBLASTIC LEUKEMIA

LEUKEMIA

SARCOMA

BONE MARROW

PATIENTS

Acute Myelogenous Leukemia

Leukemia Cutis

Granulocytic Sarcoma

Rearrangement

Issues

Article Details

Authors: Hebah M. El-Rayess | Marwan M. Refaat | Karim Saab | Nadim El-Jamal | Bimalangshu R. Dey

Publisher: Lebanese Order of Physicians : Scientific Committee

Main Topics: Medicine

Journal: Lebanese Medical Journal 2017 Vol.65 Issue 1, pp.55-57

Document Type: Article

Publication Date: 3/2017

Document Language: English

Document ID (Org No.): 99976

Frequency: Quarterly

pISSN: 00239852

DOI: 10.12816/0035673

Descriptors:

Issues

Authors:

Hebah M. El-Rayess | Marwan M. Refaat | Karim Saab | Nadim El-Jamal | Bimalangshu R. Dey

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2017 Vol.65 Issue 1, pp.55-57

Document Type:

Article

Publication Date:

3/2017

Document Language:

English

Document ID (Org No.):

99976

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0035673