Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats

Zuhal UÇKUN ŞAHİNOĞULLARI; Sevda GÜZEL; Necmiye CANACANKATAN; Cem YALAZA; Deniz KİBAR; Gulsen BAYRAK

doi:https://doi.org/10.33808/clinexphealthsci.741916

Article Details

Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats

Authors:

Zuhal UÇKUN ŞAHİNOĞULLARI | Sevda GÜZEL | Necmiye CANACANKATAN | Cem YALAZA | Deniz KİBAR | Gulsen BAYRAK

Publisher:

Marmara University

Main Topics:

Promotion of health

Journal:

Clinical and Experimental Health Sciences 2021 Vol.11 Issue 2, pp.191-198

Document Type:

Article

Publication Date:

6/2021

Document Language:

English

Document ID (Org No.):

2000906792

Frequency:

Monthly

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.741916

Abstract:

 


Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers of apoptosis and the levels of tumor necrosis factor-alpha, cyclooxygenase-2 and vascular endothelial growth factor as inflammation markers and assessing the histopathological alterations in rats. 

  

Methods: The rats were allocated into seven groups as, the control group (saline, intraperitoneally (i.p.)), VCM group (400 mg/kg/day, i.p.), Carboxymethyl cellulose group (0.5% CMC, orally), NAR100 group (100 mg/kg/day, orally), VCM+NAR25 group (25 mg/kg/day, orally), VCM+NAR50 group (50 mg/kg/day, orally), VCM+NAR100 group (100 mg/kg/day, orally). The caspase enzyme activities and inflammation markers were measured using colorimetric methods and ELISA, respectively. Histopathological examinations were performed. 


Results: The caspase activities and levels of inflammation markers were significantly higher in the VCM group as opposed to the other groups. The caspase activities were significantly ameliorated in the VCM+NAR25 group compared to the VCM+NAR50 and VCM+NAR100 groups, but the levels of inflammation markers were significantly attenuated in VCM+NAR50 group and, especially, VCM+NAR100 group compared to VCM+NAR25 group. 


Conclusion: NAR has potential protective impact on liver injury caused by VCM, and the protective impacts of NAR at distinct doses may occur via different molecular mechanisms.

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Article Details

Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats

Authors: Zuhal UÇKUN ŞAHİNOĞULLARI | Sevda GÜZEL | Necmiye CANACANKATAN | Cem YALAZA | Deniz KİBAR | Gulsen BAYRAK

Publisher: Marmara University

Main Topics: Promotion of health

Journal: Clinical and Experimental Health Sciences 2021 Vol.11 Issue 2, pp.191-198

Document Type: Article

Publication Date: 6/2021

Document Language: English

Document ID (Org No.): 2000906792

Frequency: Monthly

eISSN: 2459-1459

DOI: https://doi.org/10.33808/clinexphealthsci.741916

Issues

Authors:

Zuhal UÇKUN ŞAHİNOĞULLARI | Sevda GÜZEL | Necmiye CANACANKATAN | Cem YALAZA | Deniz KİBAR | Gulsen BAYRAK

Publisher:

Marmara University

Main Topics:

Promotion of health

Journal:

Clinical and Experimental Health Sciences 2021 Vol.11 Issue 2, pp.191-198

Document Type:

Article

Publication Date:

6/2021

Document Language:

English

Document ID (Org No.):

2000906792

Frequency:

Monthly

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.741916