Can plasma fibrinogen level predict bone marrow fibrosis?

N.A.

Article Details

Can plasma fibrinogen level predict bone marrow fibrosis?

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.80-86

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283555

pISSN:

1019-1941

Keywords:

Abstract:

 Objective: We aimed to assess the possible relationship between plasma fibrinogen level and bone marrow fibrosis BMF grades in patients who had undergone bone marrow BM biopsy for any reason. Patients and Method: This retrospective cohort study included 106 participants aged 18 years and over who had undergone simultaneous BM biopsy and circulatory fibrinogen level measurement during 2020 and 2021 at our center. BMF grade was measured by the modified Bauermeister grading system MBGS. Participants were divided into two groups according to MBGS as those without BMF and those with BMF. Results: Fifty-eight male were included in our study, and the median age of the patients was 63 range: 19-97 years. Fibrinogen p0.004 and lactate dehydrogenase LDH p0.030 levels were significantly higher in the fibrosis group. Multiple regression revealed that high fibrinogen 359 and high LDH 238 were independently associated with a higher likelihood of fibrosis presence adjusted for age and sex; however, diagnostic analyses revealed low accuracy. Conclusion: High plasma fibrinogen and LDH levels were found to be independently associated with the presence of BMF. However, it was also evident that neither of these parameters could be used for diagnostic purposes.

 Objective: We aimed to assess the possible relationship between plasma fibrinogen level and bone marrow fibrosis BMF grades in patients who had undergone bone marrow BM biopsy for any reason. Patients and Method: This retrospective cohort study included 106 participants aged 18 years and over who had undergone simultaneous BM biopsy and circulatory fibrinogen level measurement during 2020 and 2021 at our center. BMF grade was measured by the modified Bauermeister grading system MBGS. Participants were divided into two groups according to MBGS as those without BMF and those with BMF. Results: Fifty-eight male were included in our study, and the median age of the patients was 63 range: 19-97 years. Fibrinogen p0.004 and lactate dehydrogenase LDH p0.030 levels were significantly higher in the fibrosis group. Multiple regression revealed that high fibrinogen 359 and high LDH 238 were independently associated with a higher likelihood of fibrosis presence adjusted for age and sex; however, diagnostic analyses revealed low accuracy. Conclusion: High plasma fibrinogen and LDH levels were found to be independently associated with the presence of BMF. However, it was also evident that neither of these parameters could be used for diagnostic purposes.

 Objective: We aimed to assess the possible relationship between plasma fibrinogen level and bone marrow fibrosis BMF grades in patients who had undergone bone marrow BM biopsy for any reason. Patients and Method: This retrospective cohort study included 106 participants aged 18 years and over who had undergone simultaneous BM biopsy and circulatory fibrinogen level measurement during 2020 and 2021 at our center. BMF grade was measured by the modified Bauermeister grading system MBGS. Participants were divided into two groups according to MBGS as those without BMF and those with BMF. Results: Fifty-eight male were included in our study, and the median age of the patients was 63 range: 19-97 years. Fibrinogen p0.004 and lactate dehydrogenase LDH p0.030 levels were significantly higher in the fibrosis group. Multiple regression revealed that high fibrinogen 359 and high LDH 238 were independently associated with a higher likelihood of fibrosis presence adjusted for age and sex; however, diagnostic analyses revealed low accuracy. Conclusion: High plasma fibrinogen and LDH levels were found to be independently associated with the presence of BMF. However, it was also evident that neither of these parameters could be used for diagnostic purposes.

 Objective: We aimed to assess the possible relationship between plasma fibrinogen level and bone marrow fibrosis BMF grades in patients who had undergone bone marrow BM biopsy for any reason. Patients and Method: This retrospective cohort study included 106 participants aged 18 years and over who had undergone simultaneous BM biopsy and circulatory fibrinogen level measurement during 2020 and 2021 at our center. BMF grade was measured by the modified Bauermeister grading system MBGS. Participants were divided into two groups according to MBGS as those without BMF and those with BMF. Results: Fifty-eight male were included in our study, and the median age of the patients was 63 range: 19-97 years. Fibrinogen p0.004 and lactate dehydrogenase LDH p0.030 levels were significantly higher in the fibrosis group. Multiple regression revealed that high fibrinogen 359 and high LDH 238 were independently associated with a higher likelihood of fibrosis presence adjusted for age and sex; however, diagnostic analyses revealed low accuracy. Conclusion: High plasma fibrinogen and LDH levels were found to be independently associated with the presence of BMF. However, it was also evident that neither of these parameters could be used for diagnostic purposes.

Article Details

Can plasma fibrinogen level predict bone marrow fibrosis?

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.80-86

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283555

pISSN:

1019-1941

Bone marrow fibrosis

Plasma fibrinogen

Lactate dehydrogenase

Modified Bauermeister grading system

Bone marrow fibrosis

Plasma fibrinogen

Lactate dehydrogenase

Modified Bauermeister grading system

Issues

Article Details

Authors: N.A.

Publisher: Marmara University

Main Topics: Clinical Sciences

Journal: Marmara Medical Journal Vol.36 Issue 1, pp.80-86

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001283555

pISSN: 1019-1941

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.80-86

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283555

pISSN:

1019-1941