Effects of The Hydroxyurea Derivative 1, 3 ,4 - Thiadiazoles on Antioxidant Vitamins and MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells

Yusuf KARAGOZOGLU

doi:https://doi.org/10.37212/jcnos.607128

Article Details

Effects of The Hydroxyurea Derivative 1, 3 ,4 - Thiadiazoles on Antioxidant Vitamins and MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells

Authors:

Yusuf KARAGOZOGLU

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2015 Vol.7 Issue 2, pp.439-445

Document Type:

Article

Publication Date:

8/2015

Document Language:

English

Document ID (Org No.):

2000708942

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.607128

Abstract:

 





In this study, the effects of as used
ligand [1-hydroxy - 2 - (5 - (trifluoromethyl) - 1, 3, 4- thiadiazole- 2 - yl) guanidine]
and its Mn, Cd, Cr complexes on the antioxidant vitamins and MDA levels in the
serums of rats and antitumor activity of these chemical compounds on the MCF-7
breast cancer cells at different concentrations were investigated. When the
results were compared between the levels of control and experimental groups of
antioxidant vitamins and MDA statistically, it was observed that there were
decreased levels of A, E, and C vitamins in groups of applied Cd (II) and Cr
(II) complexes compared with the control group, 
whereas MDA levels were increased. The antioxidant vitamins and MDA
levels in serum were determined by HPLC. It was clearly observed that the
subcutaneously MCF-7 breast cancer cells treated Ligand (L), Mn (L) 2, Cd (L) 2
and Cr (L) 2 complexes had the low levels of cell viability activity when
compared to the untreated control cells clearly increased according to the
control group for after incubation 24 h onwards to 48 h. Cell vialities
measured by electronic microscope. As a result, it suggested that thiadiazole
compounds exhibit antitumor activity with reduction in serum antioxidant
vitamins of rats can cause cytotoxic effect depending on the mechanism of
oxidative damage.




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Article Details

Effects of The Hydroxyurea Derivative 1, 3 ,4 - Thiadiazoles on Antioxidant Vitamins and MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells

Authors: Yusuf KARAGOZOGLU

Publisher: Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal: Journal of Cellular Neuroscience and Oxidative Stress 2015 Vol.7 Issue 2, pp.439-445

Document Type: Article

Publication Date: 8/2015

Document Language: English

Document ID (Org No.): 2000708942

Frequency: Tri-annual

eISSN: 2149-7222

DOI: https://doi.org/10.37212/jcnos.607128

Issues

Authors:

Yusuf KARAGOZOGLU

Publisher:

Hücresel Sinir Bilimleri ve Oksidatif Stres Derneği

Journal:

Journal of Cellular Neuroscience and Oxidative Stress 2015 Vol.7 Issue 2, pp.439-445

Document Type:

Article

Publication Date:

8/2015

Document Language:

English

Document ID (Org No.):

2000708942

Frequency:

Tri-annual

eISSN:

2149-7222

DOI:

https://doi.org/10.37212/jcnos.607128