Evaluation of the Relationship between Simple Hemogram Indexes and Disease Severity Scores in Pediatric Familial Mediterranean Fever

Vildan GÜNGÖRER; Şükrü  ARSLAN

doi:https://doi.org/10.18678/dtfd.1037824

Article Details

Evaluation of the Relationship between Simple Hemogram Indexes and Disease Severity Scores in Pediatric Familial Mediterranean Fever

Authors:

Vildan GÜNGÖRER | Şükrü ARSLAN

Publisher:

Duzce University

Main Topics:

Diseases

Journal:

Duzce Medical Journal 2022 Vol.24 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

4/2022

Document Language:

English

Document ID (Org No.):

2000943812

Frequency:

Tri-annual

eISSN:

1307-671X

DOI:

https://doi.org/10.18678/dtfd.1037824

Keywords:

Abstract:

 

Aim: In recent years, it has been seen that simple complete blood count (CBC) parameters can be used to show subclinical inflammation in patients with familial Mediterranean fever (FMF). The aim of this study is to determine whether there is a difference in CBC parameters among FMF patient groups divided according to disease severity scores.
Material and Methods: FMF patients followed up in our clinic between 2016 and 2019, were reviewed for medical records. They were divided into three groups as those with mild, moderate, and severe diseases according to the disease severity scoring systems by Pras et al., Mor et al., and International Severity Score of FMF (ISSF). Red cell distribution width (RDW), platelet, neutrophil, lymphocyte, RDW-platelet ratio (RPR), platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) of the patients were compared among the groups.
Results: According to the scoring system of Pras et al., lymphocyte value was found significantly higher in the group with severe disease compared to the groups with mild and moderate diseases (p=0.031). PLR was significantly lower in the group with severe disease compared to moderate diseases according to the scoring system of Mor et al (p=0.008). According to ISSF, there was no difference among the groups in terms of CBC parameters.
Conclusion: Different results were obtained according to all three scoring systems. Since the ISSF is the most common and suitable system for use in FMF patients, we can conclude that there is no relationship between disease severity and RDW, RPR, NLR and PLR.

 

Amaç: Son yıllarda, AAA hastalarında subklinik inflamasyonu göstermek için basit tam kan sayımı (TKS) parametrelerinin kullanılabileceği görülmüştür. Bu çalışmanın amacı, hastalık şiddeti skorlarına göre ayrılan AAA hasta grupları arasında TKS parametrelerinde farklılık olup olmadığını belirlemektir.
Gereç ve Yöntemler: Kliniğimizde 2016 ve 2019 yılları arasında takip edilen AAA hastalarının tıbbi kayıtları incelendi. Hastalar, Pras ve ark., Mor ve ark. ve AAA için uluslararası şiddet skorlama sistemi (International Severity Score for FMF, ISSF) hastalık şiddeti skorlama sistemlerine göre hafif, orta ve ağır hastalığı olanlar olmak üzere üç gruba ayrıldı. Hastaların eritrosit dağılım genişliği (red cell distribution width, RDW), trombosit, nötrofil, lenfosit, RDW-trombosit oranı (RDW-platelet ratio, RPR), trombosit-lenfosit oranı (platelet-lymphocyte ratio, PLR) ve nötrofil-lenfosit oranı (neutrophil-lymphocyte ratio, NLR) gruplar arasında karşılaştırıldı.
Bulgular: Pras ve ark.’nın skorlama sistemine göre, şiddetli hastalığı olan grupta lenfosit değerinin hafif ve orta derecede hastalığı olan gruplara göre anlamlı derecede yüksek olduğu bulundu (p=0,031). Mor ve ark.’nın skorlama sistemine göre PLR, şiddetli hastalığı olan grupta orta dereceli hastalıklara göre anlamlı olarak daha düşüktü (p=0,008). ISSF skorlamasına göre, TKS parametreleri açısından gruplar arasında fark yoktu.
Sonuç: Her üç skorlama sistemine göre de farklı sonuçlar elde edildi. ISSF, AAA hastalarında en yaygın ve kullanıma uygun sistem olduğundan, hastalık şiddeti ile RDW, RPR, NLR ve PLR arasında bir ilişki olmadığı sonucuna varabiliriz.

Article Details

Evaluation of the Relationship between Simple Hemogram Indexes and Disease Severity Scores in Pediatric Familial Mediterranean Fever

Authors:

Vildan GÜNGÖRER | Şükrü ARSLAN

Publisher:

Duzce University

Main Topics:

Diseases

Journal:

Duzce Medical Journal 2022 Vol.24 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

4/2022

Document Language:

English

Document ID (Org No.):

2000943812

Frequency:

Tri-annual

eISSN:

1307-671X

DOI:

https://doi.org/10.18678/dtfd.1037824

Tam kan sayımı

hastalık şiddeti indeksi

Ailesel Akdeniz Ateşi

Issues

Article Details

Evaluation of the Relationship between Simple Hemogram Indexes and Disease Severity Scores in Pediatric Familial Mediterranean Fever

Authors: Vildan GÜNGÖRER | Şükrü ARSLAN

Publisher: Duzce University

Main Topics: Diseases

Journal: Duzce Medical Journal 2022 Vol.24 Issue 1, pp.18-25

Document Type: Article

Publication Date: 4/2022

Document Language: English

Document ID (Org No.): 2000943812

Frequency: Tri-annual

eISSN: 1307-671X

DOI: https://doi.org/10.18678/dtfd.1037824

Tam kan sayımı

hastalık şiddeti indeksi

Ailesel Akdeniz Ateşi

Issues

Authors:

Vildan GÜNGÖRER | Şükrü ARSLAN

Publisher:

Duzce University

Main Topics:

Diseases

Journal:

Duzce Medical Journal 2022 Vol.24 Issue 1, pp.18-25

Document Type:

Article

Publication Date:

4/2022

Document Language:

English

Document ID (Org No.):

2000943812

Frequency:

Tri-annual

eISSN:

1307-671X

DOI:

https://doi.org/10.18678/dtfd.1037824