FeNO, systemic inflammation and other risk factors for osteoporosis in COPD

Ömür Güngör; A.  Füsun Kalpaklıoğlu

Article Details

FeNO, systemic inflammation and other risk factors for osteoporosis in COPD

Authors:

Ömür Güngör | A. Füsun Kalpaklıoğlu

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Journal of Health Sciences and Medicine Vol.6 Issue 1, pp.122-127

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001282296

pISSN:

2636-8579

Keywords:

Abstract:

 Aim: The bone is one of the tissues that is adversely affected as a result of inflammation in COPD. The aim of this study is to examine the relationship between airway inflammation, systemic inflammation and osteoporosis in COPD. Material and Method: A cross-sectional study was performed, including 50 patients with stable COPD. FeNO as a marker of airway inflammation; hs-CRP, WBC and fibrinogen as systemic inflammation markers; arterial blood gas, BMI and FEV1 were measured. To identify osteoporosis, DEXA was performed. Results: The prevalence of osteoporosis was 26. Osteoporosis was associated with WBC and hs-CRP OR: 1.80, 95 CI, 1.26-2.57 and OR: 2.32, 95 CI, 1.28-4.20, respectively. It was observed that the risk increased as FEV1 and BMI decreased OR: 0.94, 95 CI, 0.89-0.98 and OR: 0.75, 95 CI, 0.61-0.91, respectively. There was no relationship between osteoporosis and FeNO and fibrinogen OR: 1.05, 95 CI, 0.99-1.12 and OR: 1.04, 95 CI 0.98-1.09, respectively. Arterial blood gases PaO2 and PaCO2 were not effective on osteoporosis OR: 1.01, 95 CI, 0.95-1.05 and OR: 1.04, 95 CI, 0.90-1.19, respectively. The cut-off values of hs-CRP and WBC for osteoporosis risk were 15.9 mgL and 11.6 10⁹L, respectively. Conclusions: Osteoporosis was associated with low BMI, airway stenosis and high levels of hs-CRP and WBC.

 Aim: The bone is one of the tissues that is adversely affected as a result of inflammation in COPD. The aim of this study is to examine the relationship between airway inflammation, systemic inflammation and osteoporosis in COPD. Material and Method: A cross-sectional study was performed, including 50 patients with stable COPD. FeNO as a marker of airway inflammation; hs-CRP, WBC and fibrinogen as systemic inflammation markers; arterial blood gas, BMI and FEV1 were measured. To identify osteoporosis, DEXA was performed. Results: The prevalence of osteoporosis was 26. Osteoporosis was associated with WBC and hs-CRP OR: 1.80, 95 CI, 1.26-2.57 and OR: 2.32, 95 CI, 1.28-4.20, respectively. It was observed that the risk increased as FEV1 and BMI decreased OR: 0.94, 95 CI, 0.89-0.98 and OR: 0.75, 95 CI, 0.61-0.91, respectively. There was no relationship between osteoporosis and FeNO and fibrinogen OR: 1.05, 95 CI, 0.99-1.12 and OR: 1.04, 95 CI 0.98-1.09, respectively. Arterial blood gases PaO2 and PaCO2 were not effective on osteoporosis OR: 1.01, 95 CI, 0.95-1.05 and OR: 1.04, 95 CI, 0.90-1.19, respectively. The cut-off values of hs-CRP and WBC for osteoporosis risk were 15.9 mgL and 11.6 10⁹L, respectively. Conclusions: Osteoporosis was associated with low BMI, airway stenosis and high levels of hs-CRP and WBC.

 Aim: The bone is one of the tissues that is adversely affected as a result of inflammation in COPD. The aim of this study is to examine the relationship between airway inflammation, systemic inflammation and osteoporosis in COPD. Material and Method: A cross-sectional study was performed, including 50 patients with stable COPD. FeNO as a marker of airway inflammation; hs-CRP, WBC and fibrinogen as systemic inflammation markers; arterial blood gas, BMI and FEV1 were measured. To identify osteoporosis, DEXA was performed. Results: The prevalence of osteoporosis was 26. Osteoporosis was associated with WBC and hs-CRP OR: 1.80, 95 CI, 1.26-2.57 and OR: 2.32, 95 CI, 1.28-4.20, respectively. It was observed that the risk increased as FEV1 and BMI decreased OR: 0.94, 95 CI, 0.89-0.98 and OR: 0.75, 95 CI, 0.61-0.91, respectively. There was no relationship between osteoporosis and FeNO and fibrinogen OR: 1.05, 95 CI, 0.99-1.12 and OR: 1.04, 95 CI 0.98-1.09, respectively. Arterial blood gases PaO2 and PaCO2 were not effective on osteoporosis OR: 1.01, 95 CI, 0.95-1.05 and OR: 1.04, 95 CI, 0.90-1.19, respectively. The cut-off values of hs-CRP and WBC for osteoporosis risk were 15.9 mgL and 11.6 10⁹L, respectively. Conclusions: Osteoporosis was associated with low BMI, airway stenosis and high levels of hs-CRP and WBC.

 Aim: The bone is one of the tissues that is adversely affected as a result of inflammation in COPD. The aim of this study is to examine the relationship between airway inflammation, systemic inflammation and osteoporosis in COPD. Material and Method: A cross-sectional study was performed, including 50 patients with stable COPD. FeNO as a marker of airway inflammation; hs-CRP, WBC and fibrinogen as systemic inflammation markers; arterial blood gas, BMI and FEV1 were measured. To identify osteoporosis, DEXA was performed. Results: The prevalence of osteoporosis was 26. Osteoporosis was associated with WBC and hs-CRP OR: 1.80, 95 CI, 1.26-2.57 and OR: 2.32, 95 CI, 1.28-4.20, respectively. It was observed that the risk increased as FEV1 and BMI decreased OR: 0.94, 95 CI, 0.89-0.98 and OR: 0.75, 95 CI, 0.61-0.91, respectively. There was no relationship between osteoporosis and FeNO and fibrinogen OR: 1.05, 95 CI, 0.99-1.12 and OR: 1.04, 95 CI 0.98-1.09, respectively. Arterial blood gases PaO2 and PaCO2 were not effective on osteoporosis OR: 1.01, 95 CI, 0.95-1.05 and OR: 1.04, 95 CI, 0.90-1.19, respectively. The cut-off values of hs-CRP and WBC for osteoporosis risk were 15.9 mgL and 11.6 10⁹L, respectively. Conclusions: Osteoporosis was associated with low BMI, airway stenosis and high levels of hs-CRP and WBC.

Article Details

Authors: Ömür Güngör | A. Füsun Kalpaklıoğlu

Publisher: MediHealth Academy Yayıncılık

Main Topics: Sağlık Kurumları Yönetimi

Journal: Journal of Health Sciences and Medicine Vol.6 Issue 1, pp.122-127

Document Type: Article

Publication Date: 12/2023

Document Language: English

Document ID (Org No.): 2001282296

pISSN: 2636-8579

Issues

Authors:

Ömür Güngör | A. Füsun Kalpaklıoğlu

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Journal of Health Sciences and Medicine Vol.6 Issue 1, pp.122-127

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001282296

pISSN:

2636-8579