The effect of obesity on FibroScan parameters, cytokeratin-18, and fibroblast growth factor-21 levels

Murat Keskin; Nizameddin Koca

Article Details

The effect of obesity on FibroScan parameters, cytokeratin-18, and fibroblast growth factor-21 levels

Authors:

Murat Keskin | Nizameddin Koca

Publisher:

Prusa Medical Publishing

Main Topics:

Gastroenterology and Hepatology

Journal:

The European Research Journal Vol.11 Issue 2, pp.207-216

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341274

pISSN:

2149-3189

Keywords:

Abstract:

 Objectives: This study aimed to evaluate the differences in anthropometric, clinical, laboratory, and radiological parameters between obese and non-obese adolescents, focusing on the role of FibroScan parameters, Cytokeratin-18 CK-18, and Fibroblast growth factor FGF-21 in assessing metabolic and liver health. Methods: Anthropometric data were collected, and blood pressure was measured. Laboratory parameters, including fasting glucose, insulin, HOMA-IR, liver enzymes, lipids, CK-18, and FGF-21 levels, were assessed. Liver stiffness measurement LSM and controlled attenuation parameter CAP were measured using Fibroscan. Pearsons correlation analyses were performed to identify associations between CK-18FGF-21 levels and metabolic parameters. Results: A cross-sectional study involved 193 adolescents aged 10-18, including 87 obese and 106 non-obese participants. Obese adolescents had significantly higher fasting insulin, HOMA-IR, AST, ALT, GGT, uric acid, triglycerides, and LDL-cholesterol, with lower HDL-cholesterol levels all P0.001. CK-18 P0.05 and FGF-21 levels P0.002 were elevated in the obese group. CAP and LSM values were also significantly higher in obese participants P0.001. CK-18 and FGF-21 were positively correlated with fasting insulin, HOMA-IR, GGT, and triglycerides, indicating their potential as biomarkers for metabolic dysfunction. LSM correlated significantly with CK-18 P0.005 and FGF-21 P0.007. Conclusions: Obese adolescents exhibited significant metabolic and liver dysfunction. Elevated CK-18 and FGF-21 levels, along with abnormal FibroScan parameters, highlight the importance of these biomarkers in identifying early liver injury and metabolic abnormalities. These findings suggest that CK-18 and FGF-21 may be valuable non-invasive tools for assessing and managing obesity-related liver disease.

 Objectives: This study aimed to evaluate the differences in anthropometric, clinical, laboratory, and radiological parameters between obese and non-obese adolescents, focusing on the role of FibroScan parameters, Cytokeratin-18 CK-18, and Fibroblast growth factor FGF-21 in assessing metabolic and liver health. Methods: Anthropometric data were collected, and blood pressure was measured. Laboratory parameters, including fasting glucose, insulin, HOMA-IR, liver enzymes, lipids, CK-18, and FGF-21 levels, were assessed. Liver stiffness measurement LSM and controlled attenuation parameter CAP were measured using Fibroscan. Pearsons correlation analyses were performed to identify associations between CK-18FGF-21 levels and metabolic parameters. Results: A cross-sectional study involved 193 adolescents aged 10-18, including 87 obese and 106 non-obese participants. Obese adolescents had significantly higher fasting insulin, HOMA-IR, AST, ALT, GGT, uric acid, triglycerides, and LDL-cholesterol, with lower HDL-cholesterol levels all P0.001. CK-18 P0.05 and FGF-21 levels P0.002 were elevated in the obese group. CAP and LSM values were also significantly higher in obese participants P0.001. CK-18 and FGF-21 were positively correlated with fasting insulin, HOMA-IR, GGT, and triglycerides, indicating their potential as biomarkers for metabolic dysfunction. LSM correlated significantly with CK-18 P0.005 and FGF-21 P0.007. Conclusions: Obese adolescents exhibited significant metabolic and liver dysfunction. Elevated CK-18 and FGF-21 levels, along with abnormal FibroScan parameters, highlight the importance of these biomarkers in identifying early liver injury and metabolic abnormalities. These findings suggest that CK-18 and FGF-21 may be valuable non-invasive tools for assessing and managing obesity-related liver disease.

 Objectives: This study aimed to evaluate the differences in anthropometric, clinical, laboratory, and radiological parameters between obese and non-obese adolescents, focusing on the role of FibroScan parameters, Cytokeratin-18 CK-18, and Fibroblast growth factor FGF-21 in assessing metabolic and liver health. Methods: Anthropometric data were collected, and blood pressure was measured. Laboratory parameters, including fasting glucose, insulin, HOMA-IR, liver enzymes, lipids, CK-18, and FGF-21 levels, were assessed. Liver stiffness measurement LSM and controlled attenuation parameter CAP were measured using Fibroscan. Pearsons correlation analyses were performed to identify associations between CK-18FGF-21 levels and metabolic parameters. Results: A cross-sectional study involved 193 adolescents aged 10-18, including 87 obese and 106 non-obese participants. Obese adolescents had significantly higher fasting insulin, HOMA-IR, AST, ALT, GGT, uric acid, triglycerides, and LDL-cholesterol, with lower HDL-cholesterol levels all P0.001. CK-18 P0.05 and FGF-21 levels P0.002 were elevated in the obese group. CAP and LSM values were also significantly higher in obese participants P0.001. CK-18 and FGF-21 were positively correlated with fasting insulin, HOMA-IR, GGT, and triglycerides, indicating their potential as biomarkers for metabolic dysfunction. LSM correlated significantly with CK-18 P0.005 and FGF-21 P0.007. Conclusions: Obese adolescents exhibited significant metabolic and liver dysfunction. Elevated CK-18 and FGF-21 levels, along with abnormal FibroScan parameters, highlight the importance of these biomarkers in identifying early liver injury and metabolic abnormalities. These findings suggest that CK-18 and FGF-21 may be valuable non-invasive tools for assessing and managing obesity-related liver disease.

 Objectives: This study aimed to evaluate the differences in anthropometric, clinical, laboratory, and radiological parameters between obese and non-obese adolescents, focusing on the role of FibroScan parameters, Cytokeratin-18 CK-18, and Fibroblast growth factor FGF-21 in assessing metabolic and liver health. Methods: Anthropometric data were collected, and blood pressure was measured. Laboratory parameters, including fasting glucose, insulin, HOMA-IR, liver enzymes, lipids, CK-18, and FGF-21 levels, were assessed. Liver stiffness measurement LSM and controlled attenuation parameter CAP were measured using Fibroscan. Pearsons correlation analyses were performed to identify associations between CK-18FGF-21 levels and metabolic parameters. Results: A cross-sectional study involved 193 adolescents aged 10-18, including 87 obese and 106 non-obese participants. Obese adolescents had significantly higher fasting insulin, HOMA-IR, AST, ALT, GGT, uric acid, triglycerides, and LDL-cholesterol, with lower HDL-cholesterol levels all P0.001. CK-18 P0.05 and FGF-21 levels P0.002 were elevated in the obese group. CAP and LSM values were also significantly higher in obese participants P0.001. CK-18 and FGF-21 were positively correlated with fasting insulin, HOMA-IR, GGT, and triglycerides, indicating their potential as biomarkers for metabolic dysfunction. LSM correlated significantly with CK-18 P0.005 and FGF-21 P0.007. Conclusions: Obese adolescents exhibited significant metabolic and liver dysfunction. Elevated CK-18 and FGF-21 levels, along with abnormal FibroScan parameters, highlight the importance of these biomarkers in identifying early liver injury and metabolic abnormalities. These findings suggest that CK-18 and FGF-21 may be valuable non-invasive tools for assessing and managing obesity-related liver disease.

Article Details

The effect of obesity on FibroScan parameters, cytokeratin-18, and fibroblast growth factor-21 levels

Authors:

Murat Keskin | Nizameddin Koca

Publisher:

Prusa Medical Publishing

Main Topics:

Gastroenterology and Hepatology

Journal:

The European Research Journal Vol.11 Issue 2, pp.207-216

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341274

pISSN:

2149-3189

Adolescent obesity

non-alcoholic fatty liver disease (NAFLD)

FibroScan

cytokeratin-18 (CK-18)

fibroblast growth factor-21 (FGF-21)

Issues

Article Details

The effect of obesity on FibroScan parameters, cytokeratin-18, and fibroblast growth factor-21 levels

Authors: Murat Keskin | Nizameddin Koca

Publisher: Prusa Medical Publishing

Main Topics: Gastroenterology and Hepatology

Journal: The European Research Journal Vol.11 Issue 2, pp.207-216

Document Type: Article

Publication Date: 4/2025

Document Language: English

Document ID (Org No.): 2001341274

pISSN: 2149-3189

Adolescent obesity

non-alcoholic fatty liver disease (NAFLD)

FibroScan

cytokeratin-18 (CK-18)

fibroblast growth factor-21 (FGF-21)

Issues

Authors:

Murat Keskin | Nizameddin Koca

Publisher:

Prusa Medical Publishing

Main Topics:

Gastroenterology and Hepatology

Journal:

The European Research Journal Vol.11 Issue 2, pp.207-216

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341274

pISSN:

2149-3189