Kallistatin as a New and Reliable Biomarker for the Diagnosis of Liver Cirrhosis

Ibrahim , Atef Abou El Fotouh; El Dahshan , Tarek Abd El Kareim; Zakarya , Zakarya Mohamed; Oadaa , Bahaa Najeeb Abd El Wahab

Article Details

Kallistatin as a New and Reliable Biomarker for the Diagnosis of Liver Cirrhosis

Authors:

Ibrahim , Atef Abou El Fotouh | El Dahshan , Tarek Abd El Kareim | Zakarya , Zakarya Mohamed | Oadaa , Bahaa Najeeb Abd El Wahab

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.3027-3032

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136266

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Cirrhosis represents the final common pathological outcome for the majority of chronic liverdiseases. Most patients with cirrhosis die from one or more clinical complications including ascites, hepaticencephalopathy and variceal hemorrhage.Objective: The aim of the study was to explore the relationship between serum kallistatin and clinical evidenceof cirrhosis and to determine if serum kallistatin levels could be used as a diagnostic indicator of hepatic healthstatus especially human liver cirrhosis.Patients and methods: The present study included 70 patients with liver cirrhosis and 25 healthy volunteersserved as controls. Cirrhotic patients were subdivided into groups A, B and C according to Child score.Results: The results in the current study revealed that there was highly significant decrease of kallistatin levelin liver cirrhosis patients compared to control group. The level of kallistatin was significantly decreased indecompensated patients more than compensated patients. These findings pointed to the value of kallistatin asa new biomarker for diagnosis of liver cirrhosis.Conclusion: Our findings support that kallistatin may be an efficient biomarker in early detection of livercirrhosis. Also combination of kallistatin with Fib4 score could improve the sensitivity and specificity forchronic liver disease.

Article Details

Kallistatin as a New and Reliable Biomarker for the Diagnosis of Liver Cirrhosis

Authors:

Ibrahim , Atef Abou El Fotouh | El Dahshan , Tarek Abd El Kareim | Zakarya , Zakarya Mohamed | Oadaa , Bahaa Najeeb Abd El Wahab

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.3027-3032

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136266

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

ENCEPHALOPATHY

FIBROSIS

LIVER DISEASES

DIAGNOSIS

Cirrhosis

Kallistatin

Encephalopathy

Issues

Article Details

Authors: Ibrahim , Atef Abou El Fotouh | El Dahshan , Tarek Abd El Kareim | Zakarya , Zakarya Mohamed | Oadaa , Bahaa Najeeb Abd El Wahab

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.3027-3032

Document Type: Article

Publication Date: 4/2019

Document Language: English

Document ID (Org No.): 136266

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Ibrahim , Atef Abou El Fotouh | El Dahshan , Tarek Abd El Kareim | Zakarya , Zakarya Mohamed | Oadaa , Bahaa Najeeb Abd El Wahab

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.75 Issue 6, pp.3027-3032

Document Type:

Article

Publication Date:

4/2019

Document Language:

English

Document ID (Org No.):

136266

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002