Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery*

Emin Serbülent GÜÇLÜ; Ayşe Ayça SARI; Erdem DİNÇ; Tuba Özcan METİN; Banu Coşkun YILMAZ; Bahar TAŞDELEN

Article Details

Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery*

Authors:

Emin Serbülent GÜÇLÜ | Ayşe Ayça SARI | Erdem DİNÇ | Tuba Özcan METİN | Banu Coşkun YILMAZ | Bahar TAŞDELEN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1401-1406

Document Type:

Article

Publication Date:

9/2016

Document Language:

Turkish

Document ID (Org No.):

2000751817

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim: The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery.   Materials and methods: Forty eyes of 20 albino rabbits were separated into MMC and INF groups. Right and left eyes of rabbits were assigned to the drug and control groups, respectively. The superior rectus muscle was disinserted, the drug was administered to the surgical area for 5 min in the drug eyes (MMC 0.2 mg/mL or INF 5 mg/mL), and physiological saline was administered to the control eyes. Surgical areas were rinsed with 10 mL of physiological saline. The disinserted muscle was then sutured to the same area using 6.0 Vicryl. The rabbits were sacrificed after 4 weeks for histopathological examination.   Results: Significant reduction was observed in fibrosis in the INF group as compared to the control group (P = 0.005). Although adhesion formation in the drug eyes reduced in the MMC and INF groups as compared to the control group, the difference was not significant (P = 0.280 and P = 0.579, respectively).   Conclusion: This study demonstrated the fibrosis-preventing efficacy of IFN; thus, it can be a good option in reducing fibrosis in strabismus surgery.

Article Details

Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery*

Authors: Emin Serbülent GÜÇLÜ | Ayşe Ayça SARI | Erdem DİNÇ | Tuba Özcan METİN | Banu Coşkun YILMAZ | Bahar TAŞDELEN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1401-1406

Document Type: Article

Publication Date: 9/2016

Document Language: Turkish

Document ID (Org No.): 2000751817

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Emin Serbülent GÜÇLÜ | Ayşe Ayça SARI | Erdem DİNÇ | Tuba Özcan METİN | Banu Coşkun YILMAZ | Bahar TAŞDELEN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1401-1406

Document Type:

Article

Publication Date:

9/2016

Document Language:

Turkish

Document ID (Org No.):

2000751817

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144