Hyperglycemic Effect of Dietary Boron in Rats with Experimental Diabetes Mellitus Induced by Streptozotocin

Nur Akman Alacabey; Gökhan Oto; Hulya Ozdemir

Article Details

Hyperglycemic Effect of Dietary Boron in Rats with Experimental Diabetes Mellitus Induced by Streptozotocin

Authors:

Nur Akman Alacabey | Gökhan Oto | Hulya Ozdemir

Publisher:

Van Yuzuncu Yıl University

Main Topics:

Veteriner Farmakoloji

Journal:

Van Veterinary Journal Vol.34 Issue 3, pp.244-250

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001304292

pISSN:

2149-3359

Keywords:

Abstract:

 In this study, the effect of boric acid BA on blood sugar levels, vitamins and minerals in Streptozotocin STZ-induced diabetes in rats was investigated. In the study, 48 male Wistar albino rats 200-220 g were divided into 6 groups, no special treatment was administered to Group1, experimental diabetes was induced by administering STZ 45 mgkg through intraperitoneal IP injection to other groups. Group 2 diabetes; Group 3 6 Ukg insulin insulin; Group 4; 250 ppm, group 5; 500 ppm and group 6 1000 ppm BA mixed with their feed. Blood glucose levels of all groups were quantified from blood taken from the tail vein every week. At the end of study, the rats were sacrificed and their blood was taken. The serum levels of vitamins A, E, and minerals were studied. When compared with other groups, blood glucose levels of groups 4, 5 and 6 were found to be increased p0.05. When compared to the baseline values, it was found that Vitamin A in the group 2 and 4, vitamin E in the group 4, Cu in the group 4, 5, 6, Zn, Mg and Na in the group 2 decreased and Fe in the group 2 increased. While Ca and P decreased in groups 5 and 6, no change was observed in Al in all groups. As a result, it has been observed that boron has a hyperglycemic effect when evaluated together with vitamins and minerals in diabetic rats. Whether boron is a suitable agent in the treatment of diabetes should be evaluated with further studies.

 In this study, the effect of boric acid BA on blood sugar levels, vitamins and minerals in Streptozotocin STZ-induced diabetes in rats was investigated. In the study, 48 male Wistar albino rats 200-220 g were divided into 6 groups, no special treatment was administered to Group1, experimental diabetes was induced by administering STZ 45 mgkg through intraperitoneal IP injection to other groups. Group 2 diabetes; Group 3 6 Ukg insulin insulin; Group 4; 250 ppm, group 5; 500 ppm and group 6 1000 ppm BA mixed with their feed. Blood glucose levels of all groups were quantified from blood taken from the tail vein every week. At the end of study, the rats were sacrificed and their blood was taken. The serum levels of vitamins A, E, and minerals were studied. When compared with other groups, blood glucose levels of groups 4, 5 and 6 were found to be increased p0.05. When compared to the baseline values, it was found that Vitamin A in the group 2 and 4, vitamin E in the group 4, Cu in the group 4, 5, 6, Zn, Mg and Na in the group 2 decreased and Fe in the group 2 increased. While Ca and P decreased in groups 5 and 6, no change was observed in Al in all groups. As a result, it has been observed that boron has a hyperglycemic effect when evaluated together with vitamins and minerals in diabetic rats. Whether boron is a suitable agent in the treatment of diabetes should be evaluated with further studies.

 In this study, the effect of boric acid BA on blood sugar levels, vitamins and minerals in Streptozotocin STZ-induced diabetes in rats was investigated. In the study, 48 male Wistar albino rats 200-220 g were divided into 6 groups, no special treatment was administered to Group1, experimental diabetes was induced by administering STZ 45 mgkg through intraperitoneal IP injection to other groups. Group 2 diabetes; Group 3 6 Ukg insulin insulin; Group 4; 250 ppm, group 5; 500 ppm and group 6 1000 ppm BA mixed with their feed. Blood glucose levels of all groups were quantified from blood taken from the tail vein every week. At the end of study, the rats were sacrificed and their blood was taken. The serum levels of vitamins A, E, and minerals were studied. When compared with other groups, blood glucose levels of groups 4, 5 and 6 were found to be increased p0.05. When compared to the baseline values, it was found that Vitamin A in the group 2 and 4, vitamin E in the group 4, Cu in the group 4, 5, 6, Zn, Mg and Na in the group 2 decreased and Fe in the group 2 increased. While Ca and P decreased in groups 5 and 6, no change was observed in Al in all groups. As a result, it has been observed that boron has a hyperglycemic effect when evaluated together with vitamins and minerals in diabetic rats. Whether boron is a suitable agent in the treatment of diabetes should be evaluated with further studies.

 Bu çalışmada ratlarda Streptozotosin STZ ile oluşturulan diyabetes mellitüste borik asidin BAin kan şeker, vitamin ve mineral düzeyleri üzerine etkisi araştırıldı. Sunulan çalışmada 48 adet erkek Wistar albino rat 200-220 g 6 gruba ayrıldı, Grup 1e özel bir tedavi uygulanmadı, diğer gruplara intraperitonal İP 45 mgkg STZ uygulanarak deneysel diyabet oluşturuldu. Grup 2 diyabet grubu; Grup 3 6 Ukg insülin insülin grubu; Grup 4, 5 ve 6nın yemlerine sırasıyla 250, 500 ve 1000 ppm BA katıldı. Tüm grupların kan glikoz seviyesi haftalık olarak ölçüldü. Çalışmanın sonunda sıçanlar anestezi altında kan örnekleri alındıktan sonra sakrifiye edildi. Elde edilen serum örneklerinden A ve E vitamin ile bazı mineraller ölçüldü. Kan glikoz düzeylerinin 4, 5 ve 6. gruplarda arttığı belirlendi p0,05. Başlangıç değerleri ile karşılaştırıldığında 2 ve 4. grupta A vitamini, 4. grupta E vitamini, 4, 5 ve 6. gruplarda Cu, 2. grupta Zn, Mg, Na ve Fe düzeylerinin azaldığı tespit edildi. 5. ve 6. gruplarda Ca ve P azalırken, tüm gruplarda Alde değişiklik gözlenmedi. Sonuç olarak, borun diyabetik sıçanlarda vitamin ve mineral düzeyleri ile birlikte değerlendirildiğinde hiperglisemik etkiye sahip olduğu gözlendi. Borun diyabet tedavisi için uygun bir ajan olup olmayacağı ileri çalışmalarla değerlendirilmelidir.

Article Details

Hyperglycemic Effect of Dietary Boron in Rats with Experimental Diabetes Mellitus Induced by Streptozotocin

Authors:

Nur Akman Alacabey | Gökhan Oto | Hulya Ozdemir

Publisher:

Van Yuzuncu Yıl University

Main Topics:

Veteriner Farmakoloji

Journal:

Van Veterinary Journal Vol.34 Issue 3, pp.244-250

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001304292

pISSN:

2149-3359

Diabetes mellitus

Boron

Streptozotocin

Vitamin

Rat

MineralBor

Diabetes mellitus

Mineral

Streptozotosin

Sıçan

Vitamin

Issues

Article Details

Authors: Nur Akman Alacabey | Gökhan Oto | Hulya Ozdemir

Publisher: Van Yuzuncu Yıl University

Main Topics: Veteriner Farmakoloji

Journal: Van Veterinary Journal Vol.34 Issue 3, pp.244-250

Document Type: Article

Publication Date: 11/2023

Document Language: English

Document ID (Org No.): 2001304292

pISSN: 2149-3359

Issues

Authors:

Nur Akman Alacabey | Gökhan Oto | Hulya Ozdemir

Publisher:

Van Yuzuncu Yıl University

Main Topics:

Veteriner Farmakoloji

Journal:

Van Veterinary Journal Vol.34 Issue 3, pp.244-250

Document Type:

Article

Publication Date:

11/2023

Document Language:

English

Document ID (Org No.):

2001304292

pISSN:

2149-3359