Lack of Association of Glutathione S-transferase Gene Polymorphisms in Iranian Prostate Cancer Subjects

B. Sahar Ansari; R. Vasudevan; M. Mirinargesi; I. Patimah; A. R. Sabariah; P. Pasalar; Ali Bakhshi

doi:10.3844/ajbbsp.2009.30.34

Article Details

Lack of Association of Glutathione S-transferase Gene Polymorphisms in Iranian Prostate Cancer Subjects

Authors:

B. Sahar Ansari | R. Vasudevan | M. Mirinargesi | I. Patimah | A. R. Sabariah | P. Pasalar | Ali Bakhshi

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.5 Issue 1, pp.30-34

Document Type:

Article

Publication Date:

3/2009

Document Language:

English

Document ID (Org No.):

2001397002

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2009.30.34

Keywords:

Abstract:

 Problem statement: Glutathione S-transferase is super family 
genes that encode enzymes which involve in the detoxification of the cell and 
protects DNA from damage. Conflicting results was found in several studies in 
association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer. In this 
study, we determined the association between the GSTT1 and GSTM1 gene polymorphism 
and prostate cancer in Iranian subjects as control with control subjects. Approach: 
Sixty number of sample were collected from both case and control at Milad 
hospital, Tehran, Iran who were above 40 years of old. Genomic DNA was extracted 
from blood and the detection of GSTT1 and GSTM1 genotypes was done using multiplex 
PCR method. Results: The frequency of the null alleles in GSTT1 
and GSTM1 was 15 and 41.66% respectively in prostate cancer patients and 21.66 
and 56.66% respectively in control subjects. There was no association was found 
between the polymorphism and prostate cancer among Iranian subjects (p>0.05). 
Conclusion: This study failed to show an association with GSTT1 
and GSTM1 gene polymorphisms and prostate cancer and has no susceptibility to 
Iranian prostate cancer subjects.

Article Details

Lack of Association of Glutathione S-transferase Gene Polymorphisms in Iranian Prostate Cancer Subjects

Authors: B. Sahar Ansari | R. Vasudevan | M. Mirinargesi | I. Patimah | A. R. Sabariah | P. Pasalar | Ali Bakhshi

Publisher: Science Publications

Journal: American Journal of Biochemistry and Biotechnology Vol.5 Issue 1, pp.30-34

Document Type: Article

Publication Date: 3/2009

Document Language: English

Document ID (Org No.): 2001397002

pISSN: 1558-6332

DOI: 10.3844/ajbbsp.2009.30.34

GSTT1

GSTM1

polymorphism

prostate cancer

multiplex PCR

Issues

Authors:

B. Sahar Ansari | R. Vasudevan | M. Mirinargesi | I. Patimah | A. R. Sabariah | P. Pasalar | Ali Bakhshi

Publisher:

Science Publications

Journal:

American Journal of Biochemistry and Biotechnology Vol.5 Issue 1, pp.30-34

Document Type:

Article

Publication Date:

3/2009

Document Language:

English

Document ID (Org No.):

2001397002

pISSN:

1558-6332

DOI:

10.3844/ajbbsp.2009.30.34