Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

Mahsuk Taylan

doi:https://doi.org/10.5799/ahinjs.01.2016.02.0584

Article Details

Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

Authors:

Mahsuk Taylan

Publisher:

Sağlık Araştırmaları Derneği

Main Topics:

Promotion of health

Journal:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.125-133

Document Type:

Article

Publication Date:

6/2016

Document Language:

Turkish

Document ID (Org No.):

2000833200

Frequency:

Quarterly

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/ahinjs.01.2016.02.0584

Abstract:

 


ABSTRACT

Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages.

Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses.

Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality.

Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more attentively during planning of surgical operation and postoperative period. J Clin Exp Invest 2016; 7 (2): 125-133

Key words: Survival, mortality, performance score, operated, non-small cell lung cancer


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Article Details

Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

Authors: Mahsuk Taylan

Publisher: Sağlık Araştırmaları Derneği

Main Topics: Promotion of health

Journal: Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.125-133

Document Type: Article

Publication Date: 6/2016

Document Language: Turkish

Document ID (Org No.): 2000833200

Frequency: Quarterly

eISSN: 1309-6621

pISSN: 1309-8578

DOI: https://doi.org/10.5799/ahinjs.01.2016.02.0584

Issues

Authors:

Mahsuk Taylan

Publisher:

Sağlık Araştırmaları Derneği

Main Topics:

Promotion of health

Journal:

Journal of Clinical and Experimental Investigations 2016 Vol.7 Issue 2, pp.125-133

Document Type:

Article

Publication Date:

6/2016

Document Language:

Turkish

Document ID (Org No.):

2000833200

Frequency:

Quarterly

eISSN:

1309-6621

pISSN:

1309-8578

DOI:

https://doi.org/10.5799/ahinjs.01.2016.02.0584