The relationship between renal functions and multi-drug resistant organisms in patients with ventilator-associated pneumonia

N.A.

Article Details

The relationship between renal functions and multi-drug resistant organisms in patients with ventilator-associated pneumonia

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.52-58

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283563

pISSN:

1019-1941

Keywords:

Abstract:

 Objective: Despite the increase in the frequency of multi-drug resistant organism MDRO colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant MDR pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia VAP and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of eGFR  60 mL min1.73 m2 high eGFR, n65 and eGFR  60 mLmin1.73 m2 low eGFR, n68. Results: The low eGFR group presented a significantly high MDRO ratio p0.01. With the decrease in eGFR, the frequency of grampositive MDRO did not change p0.63, while the increase in gram-negative MDRO was statistically significant p0.01. Low eGFR was found to be an independent predictor for antimicrobial resistance. Odds ratio, OR: 2.821. Conclusion: Among VAP patients, chronic renal failure is associated with increased MDRO infection. The eGFR may be used to identify mechanically ventilated patients with a high risk of MDR pneumonia.

 Objective: Despite the increase in the frequency of multi-drug resistant organism MDRO colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant MDR pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia VAP and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of eGFR  60 mL min1.73 m2 high eGFR, n65 and eGFR  60 mLmin1.73 m2 low eGFR, n68. Results: The low eGFR group presented a significantly high MDRO ratio p0.01. With the decrease in eGFR, the frequency of grampositive MDRO did not change p0.63, while the increase in gram-negative MDRO was statistically significant p0.01. Low eGFR was found to be an independent predictor for antimicrobial resistance. Odds ratio, OR: 2.821. Conclusion: Among VAP patients, chronic renal failure is associated with increased MDRO infection. The eGFR may be used to identify mechanically ventilated patients with a high risk of MDR pneumonia.

 Objective: Despite the increase in the frequency of multi-drug resistant organism MDRO colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant MDR pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia VAP and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of eGFR  60 mL min1.73 m2 high eGFR, n65 and eGFR  60 mLmin1.73 m2 low eGFR, n68. Results: The low eGFR group presented a significantly high MDRO ratio p0.01. With the decrease in eGFR, the frequency of grampositive MDRO did not change p0.63, while the increase in gram-negative MDRO was statistically significant p0.01. Low eGFR was found to be an independent predictor for antimicrobial resistance. Odds ratio, OR: 2.821. Conclusion: Among VAP patients, chronic renal failure is associated with increased MDRO infection. The eGFR may be used to identify mechanically ventilated patients with a high risk of MDR pneumonia.

 Objective: Despite the increase in the frequency of multi-drug resistant organism MDRO colonisation and infection in dialysis patients, it is not well known whether the risk of multi-drug resistant MDR pneumonia increases in mild-to-severe chronic kidney disease patients not undergoing dialysis. Therefore, we aimed to evaluate the relationship between renal functions and the risk of MDR ventilator-associated pneumonia VAP and the specific microbial pattern. Patients and Methods: A total of 133 patients who developed VAP were divided according to their renal function into two groups, an estimated glomerular filtration rate of eGFR  60 mL min1.73 m2 high eGFR, n65 and eGFR  60 mLmin1.73 m2 low eGFR, n68. Results: The low eGFR group presented a significantly high MDRO ratio p0.01. With the decrease in eGFR, the frequency of grampositive MDRO did not change p0.63, while the increase in gram-negative MDRO was statistically significant p0.01. Low eGFR was found to be an independent predictor for antimicrobial resistance. Odds ratio, OR: 2.821. Conclusion: Among VAP patients, chronic renal failure is associated with increased MDRO infection. The eGFR may be used to identify mechanically ventilated patients with a high risk of MDR pneumonia.

Article Details

The relationship between renal functions and multi-drug resistant organisms in patients with ventilator-associated pneumonia

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.52-58

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283563

pISSN:

1019-1941

Chronic kidney disease

Glomerular filtration rate

Multiple drug resistance

Risk factors

Ventilator-associated pneumonia

Chronic kidney disease

Glomerular filtration rate

Multiple drug resistance

Risk factors

Ventilator-associated pneumonia

Issues

Article Details

Authors: N.A.

Publisher: Marmara University

Main Topics: Clinical Sciences

Journal: Marmara Medical Journal Vol.36 Issue 1, pp.52-58

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001283563

pISSN: 1019-1941

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Clinical Sciences

Journal:

Marmara Medical Journal Vol.36 Issue 1, pp.52-58

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001283563

pISSN:

1019-1941