Application of Heterocyclic Compounds as Catalysts in Suzuki-Miyaura Cross-Coupling Reaction

Senem AKKOÇ

doi:https://doi.org/10.17776/csj.613060

Article Details

Application of Heterocyclic Compounds as Catalysts in Suzuki-Miyaura Cross-Coupling Reaction

Authors:

Senem AKKOÇ

Main Topics:

Astronomy and allied sciences

Journal:

Cumhuriyet Science Journal 2019 Vol.40 Issue 4, pp.854-859

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000920473

DOI:

https://doi.org/10.17776/csj.613060

Keywords:

Abstract:

 

Four different benzimidazolium salts (1-4) were prepared in three steps at 80 oC and their
structures were elucidated using spectroscopic methods. The compounds (1-4) obtained were tested in in situ medium as catalyst in the
carbon-carbon (C-C) bond formation reactions of two different boronic acid
derivatives with various aryl halides in the presence of palladium acetate
(PdOAc)2 and sodium
tertiarybutoxide (NaOBut) as a base. With this reaction, four
coupling products (5-8) were
synthesized in different yields ranging from 11 to 93%. Compound 2 from the carbene precursors tested in
the Suzuki-Miyaura cross-coupling reaction was found to be a more effective
catalyst candidate than others.

 


Dört farklı benzimidazolyum tuzu (1-4) üç basamakta 80 oC de hazırlandı
ve yapıları spektroskopik yöntemler kullanılarak aydınlatıldı. Elde edilen
bileşikler (1-4), palladyum asetat
(PdOAc)2 ve bir baz olarak sodyum
tersiyerbütoksitin (NaOBut) varlığında iki farklı boronik
asit türevi ile farklı aril halojenürlerin karbon-karbon (C-C) bağ oluşum
reaksiyonlarında katalizör olarak in situ
ortamda test edildi. Bu reaksiyon ile dört eşleşme ürünü (5-8) %11 ile %93 arasında değişen farklı verimlerde sentezlendi. Suzuki-Miyaura
çapraz eşleşme reaksiyonunda test edilen karben öncüllerinden bileşik 2 diğerlerinden daha etkili bir
katalizör adayı olduğu bulundu.

.

Article Details

Application of Heterocyclic Compounds as Catalysts in Suzuki-Miyaura Cross-Coupling Reaction

Authors:

Senem AKKOÇ

Main Topics:

Astronomy and allied sciences

Journal:

Cumhuriyet Science Journal 2019 Vol.40 Issue 4, pp.854-859

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000920473

DOI:

https://doi.org/10.17776/csj.613060

Suzuki-Miyaura

Benzimidazol

Benzimidazo

Issues

Article Details

Application of Heterocyclic Compounds as Catalysts in Suzuki-Miyaura Cross-Coupling Reaction

Authors: Senem AKKOÇ

Main Topics: Astronomy and allied sciences

Journal: Cumhuriyet Science Journal 2019 Vol.40 Issue 4, pp.854-859

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000920473

DOI: https://doi.org/10.17776/csj.613060

Suzuki-Miyaura

Benzimidazol

Benzimidazo

Issues

Authors:

Senem AKKOÇ

Main Topics:

Astronomy and allied sciences

Journal:

Cumhuriyet Science Journal 2019 Vol.40 Issue 4, pp.854-859

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000920473

DOI:

https://doi.org/10.17776/csj.613060