Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

Pelin Eroglu; Dilek Eke Karakuş; Serap Yalın; Ayla Çelik; Ali Erdinç Yalın

Article Details

Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

Authors:

Pelin Eroglu | Dilek Eke Karakuş | Serap Yalın | Ayla Çelik | Ali Erdinç Yalın

Publisher:

Istanbul University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.159-165

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001300294

pISSN:

2587-2087

Keywords:

Abstract:

 Background and Aims: The potential effects of perfluorooctane sulfonate PFOS on the environment and human health have aroused great concerns in recent years. To our knowledge, there are limited studies related with the effect of curcumin on PFOS induced damage in the literature. The existing studies are focused on DNA damage. No study has been found examining the effect on the antioxidant system. We planned this study to investigate the impact of curcumin on the antioxidant defense system response in rats exposed to PFOS. Methods: The animals were divided into six groups, with the first group used as control. Groups II to VI were orally treated with curcumin 80 mgkg, PFOS 1.25 mgkg, PFOS 1.25 mgkg  curcumin, PFOS 2.5 mgkg, and PFOS 2.5 mgkg  curcumin daily for 30 days, respectively. For oxidative stress, liver, kidney, and brain samples were homogenized. The activities of antioxidant enzymes, such as superoxide dismutase SOD, catalase CAT activities, and malondialdehyde MDA content were determined. Data from the experiments were statistically analyzed by SPSS 11.0 program. Results: Our data showed that PFOS increased MDA level, while the activities of SOD and CAT decreased. It was observed that the application of curcumin together with PFOS decreased the MDA level and increased the antioxidant enzyme activities. Conclusion: As an antioxidant, curcumin plays an important protective role against oxidative damage and inhibits PFOS-induced lipid peroxidation.

 Background and Aims: The potential effects of perfluorooctane sulfonate PFOS on the environment and human health have aroused great concerns in recent years. To our knowledge, there are limited studies related with the effect of curcumin on PFOS induced damage in the literature. The existing studies are focused on DNA damage. No study has been found examining the effect on the antioxidant system. We planned this study to investigate the impact of curcumin on the antioxidant defense system response in rats exposed to PFOS. Methods: The animals were divided into six groups, with the first group used as control. Groups II to VI were orally treated with curcumin 80 mgkg, PFOS 1.25 mgkg, PFOS 1.25 mgkg  curcumin, PFOS 2.5 mgkg, and PFOS 2.5 mgkg  curcumin daily for 30 days, respectively. For oxidative stress, liver, kidney, and brain samples were homogenized. The activities of antioxidant enzymes, such as superoxide dismutase SOD, catalase CAT activities, and malondialdehyde MDA content were determined. Data from the experiments were statistically analyzed by SPSS 11.0 program. Results: Our data showed that PFOS increased MDA level, while the activities of SOD and CAT decreased. It was observed that the application of curcumin together with PFOS decreased the MDA level and increased the antioxidant enzyme activities. Conclusion: As an antioxidant, curcumin plays an important protective role against oxidative damage and inhibits PFOS-induced lipid peroxidation.

 Background and Aims: The potential effects of perfluorooctane sulfonate PFOS on the environment and human health have aroused great concerns in recent years. To our knowledge, there are limited studies related with the effect of curcumin on PFOS induced damage in the literature. The existing studies are focused on DNA damage. No study has been found examining the effect on the antioxidant system. We planned this study to investigate the impact of curcumin on the antioxidant defense system response in rats exposed to PFOS. Methods: The animals were divided into six groups, with the first group used as control. Groups II to VI were orally treated with curcumin 80 mgkg, PFOS 1.25 mgkg, PFOS 1.25 mgkg  curcumin, PFOS 2.5 mgkg, and PFOS 2.5 mgkg  curcumin daily for 30 days, respectively. For oxidative stress, liver, kidney, and brain samples were homogenized. The activities of antioxidant enzymes, such as superoxide dismutase SOD, catalase CAT activities, and malondialdehyde MDA content were determined. Data from the experiments were statistically analyzed by SPSS 11.0 program. Results: Our data showed that PFOS increased MDA level, while the activities of SOD and CAT decreased. It was observed that the application of curcumin together with PFOS decreased the MDA level and increased the antioxidant enzyme activities. Conclusion: As an antioxidant, curcumin plays an important protective role against oxidative damage and inhibits PFOS-induced lipid peroxidation.

 Background and Aims: The potential effects of perfluorooctane sulfonate PFOS on the environment and human health have aroused great concerns in recent years. To our knowledge, there are limited studies related with the effect of curcumin on PFOS induced damage in the literature. The existing studies are focused on DNA damage. No study has been found examining the effect on the antioxidant system. We planned this study to investigate the impact of curcumin on the antioxidant defense system response in rats exposed to PFOS. Methods: The animals were divided into six groups, with the first group used as control. Groups II to VI were orally treated with curcumin 80 mgkg, PFOS 1.25 mgkg, PFOS 1.25 mgkg  curcumin, PFOS 2.5 mgkg, and PFOS 2.5 mgkg  curcumin daily for 30 days, respectively. For oxidative stress, liver, kidney, and brain samples were homogenized. The activities of antioxidant enzymes, such as superoxide dismutase SOD, catalase CAT activities, and malondialdehyde MDA content were determined. Data from the experiments were statistically analyzed by SPSS 11.0 program. Results: Our data showed that PFOS increased MDA level, while the activities of SOD and CAT decreased. It was observed that the application of curcumin together with PFOS decreased the MDA level and increased the antioxidant enzyme activities. Conclusion: As an antioxidant, curcumin plays an important protective role against oxidative damage and inhibits PFOS-induced lipid peroxidation.

Article Details

Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

Authors:

Pelin Eroglu | Dilek Eke Karakuş | Serap Yalın | Ayla Çelik | Ali Erdinç Yalın

Publisher:

Istanbul University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.159-165

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001300294

pISSN:

2587-2087

Curcumin

perfluorooctane sulfonate

antioxidant

oxidative stress

lipid peroxidati

Issues

Article Details

Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

Authors: Pelin Eroglu | Dilek Eke Karakuş | Serap Yalın | Ayla Çelik | Ali Erdinç Yalın

Publisher: Istanbul University

Main Topics: Pharmacology and Pharmaceutical Sciences

Journal: İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.159-165

Document Type: Article

Publication Date: 8/2023

Document Language: English

Document ID (Org No.): 2001300294

pISSN: 2587-2087

Curcumin

perfluorooctane sulfonate

antioxidant

oxidative stress

lipid peroxidati

Issues

Authors:

Pelin Eroglu | Dilek Eke Karakuş | Serap Yalın | Ayla Çelik | Ali Erdinç Yalın

Publisher:

Istanbul University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

İstanbul Journal of Pharmacy Vol.53 Issue 2, pp.159-165

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001300294

pISSN:

2587-2087