Microfluidic Devices: A New Paradigm in Toxicity Studies

İffet İpek BOŞGELMEZ; Kutay İÇÖZ; Fatma Esra YİĞİT

doi:https://doi.org/10.15671/hjbc.610448

Article Details

Microfluidic Devices: A New Paradigm in Toxicity Studies

Authors:

İffet İpek BOŞGELMEZ | Kutay İÇÖZ | Fatma Esra YİĞİT

Publisher:

Hacettepe University

Main Topics:

Applied physics

Journal:

Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 3, pp.245-263

Document Type:

Article

Publication Date:

6/2020

Document Language:

English

Document ID (Org No.):

2000448257

Frequency:

Quarterly

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.610448

Abstract:

 


In recent
years, great emphasis has been placed on non-animal toxicological methods (e.g.in
vitro models,in silico or −omics data) as alternative strategies to reduce
animal-testing, in line with the 3R principle. These methods help in the rapid
and accurate estimation of preclinical efficacy and safety associated with discovery
of new drugs, and reduction of failure rates in clinical trials. Currently, the
in vitro studies have been in a transformation or replacement from
two-dimensional cell cultures to three-dimensional cell cultures that can mimic
the physiology of tissues, organs, and organism. 


In this
context, organ-on-a-chip systems have been developed by integration of
three-dimensional culture models with emerging microfluidic technologies. The
organ-on-a-chip systems provide a good understanding of dose-response and
toxicity mechanisms in drug development process, since impact of xenobiotics on
human body can be predicted in a satisfactory level. Besides, these systems may
support assessment of pharmacokinetic-pharmacodynamic parameters as well as detection
of drug resistance. Models can be generated as “disease-models-on-a-chip” or
with healthy cells to evaluate response to xenobiotic under test.


In this study,
we will focus on microfluidic systems being used in organ-on-a-chip systems and
emphasize their potential for toxicity studies in which micro-environments of examples
including liver,kidney,brain,lung,heart,and intestines and their physiological
properties as reflected to organ-on-a-chip models.


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Article Details

Microfluidic Devices: A New Paradigm in Toxicity Studies

Authors: İffet İpek BOŞGELMEZ | Kutay İÇÖZ | Fatma Esra YİĞİT

Publisher: Hacettepe University

Main Topics: Applied physics

Journal: Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 3, pp.245-263

Document Type: Article

Publication Date: 6/2020

Document Language: English

Document ID (Org No.): 2000448257

Frequency: Quarterly

eISSN: 2687-475X

pISSN: 2687-475X

DOI: https://doi.org/10.15671/hjbc.610448

Issues

Authors:

İffet İpek BOŞGELMEZ | Kutay İÇÖZ | Fatma Esra YİĞİT

Publisher:

Hacettepe University

Main Topics:

Applied physics

Journal:

Hacettepe Journal of Biology and Chemistry 2020 Vol.48 Issue 3, pp.245-263

Document Type:

Article

Publication Date:

6/2020

Document Language:

English

Document ID (Org No.):

2000448257

Frequency:

Quarterly

eISSN:

2687-475X

pISSN:

2687-475X

DOI:

https://doi.org/10.15671/hjbc.610448