Assessment of Serum Vitamin D Level before and after Narrowband Therapy in Vitiligo

Abou Khodair , Hassan; Amer , Ahmed Wahhed-Allah; Abd Al Samee , Hesham Samir; Gad , Naglaa Fathy Arafat

Article Details

Assessment of Serum Vitamin D Level before and after Narrowband Therapy in Vitiligo

Authors:

Abou Khodair , Hassan | Amer , Ahmed Wahhed-Allah | Abd Al Samee , Hesham Samir | Gad , Naglaa Fathy Arafat

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 2, pp.310-317

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

135618

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Vitiligo is an acquired, progressive, multifactorial, depigmenting disorder characterized by the appearance of circumscribed white macules in the skin due to chronic progressive loss of functional melanocytes in the epidermis. The etiology of vitiligo is not clear, although various hypotheses have been proposed.Objective: To evaluate the serum levels and the possible role of 25 OH vit D in vitiligo and to detect whether its level is modulated by Narrowband ultraviolet (B NB-UVB) therapy.Patients and Methods: The current study included 30 patients with vitiligo. In addition, 30 healthy subjects who were age and gender matched, served as a control group. All persons were recruited from the outpatient clinic of Al-Azhar University hospital (Damitta) and from Dermatology, Leprosy and Venereology Mansoura Hospital, from March 2018 to June 2018.Results: Vitamin D levels were lower in patients with vitiligo as compared to the control subjects. Levels of vitamin D increased significantly after NB-UVB therapy. Also, VASI scores showed improvement after NB-UVB therapy. The mean VASI score in both groups showed highly significant decrease after treatment by NB-UVB. Comparison and correlation between VASI before NB- UVB therapy and 25(OH) D showed good negative correlation.Conclusion: Decreased vitamin D serum level was found in vitiligo patients, indicating its possible involvement in the pathogenesis of the disease. This level was increased significantly after NB-UVB therapy. In addition, vitamin D serum level correlated negatively with the severity of the disease.

Article Details

Assessment of Serum Vitamin D Level before and after Narrowband Therapy in Vitiligo

Authors:

Abou Khodair , Hassan | Amer , Ahmed Wahhed-Allah | Abd Al Samee , Hesham Samir | Gad , Naglaa Fathy Arafat

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 2, pp.310-317

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

135618

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

SKIN DISEASES

VITAMIN D

MELANOCYTES

HORMONES

THERAPY

Narrowband Ultraviolet B

Vitiligo

Melanocyte Stimulating Hormones

Issues

Article Details

Authors: Abou Khodair , Hassan | Amer , Ahmed Wahhed-Allah | Abd Al Samee , Hesham Samir | Gad , Naglaa Fathy Arafat

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 2, pp.310-317

Document Type: Article

Publication Date: 1/2019

Document Language: English

Document ID (Org No.): 135618

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Abou Khodair , Hassan | Amer , Ahmed Wahhed-Allah | Abd Al Samee , Hesham Samir | Gad , Naglaa Fathy Arafat

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2019 Vol.74 Issue 2, pp.310-317

Document Type:

Article

Publication Date:

1/2019

Document Language:

English

Document ID (Org No.):

135618

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002