Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice

Mohammud M. Ali; Mele Jesmin; Mohammud K. Islam; Fatema Khatun; Abul K. Azad

doi:10.12816/0001498

Article Details

Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice

Authors:

Mohammud M. Ali | Mele Jesmin | Mohammud K. Islam | Fatema Khatun | Abul K. Azad

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2013 vol.21 Issue 3, pp.97-104

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

39338

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0001498

Descriptors:

Keywords:

Abstract:

 A schiff base acetone semicarbazone has been synthesized and characterized. Its anticanceractivities have been studied against Ehrlich Ascites Carcinoma (EAC) cells in swiss albino mice by monitoringthe parameters like tumour cell growth inhibition, tumour weight, survival time, peritoneal cells andhaematological parameters. It was found that this compound significantly reduces tumour cell growth rate,decreases tumour weight and increases life span in comparison to those of EAC bearing mice. The test compoundrestored the depleted haematological parameters of EAC bearing mice towards normal. The compoundalso enhanced number of macrophages in normal mice. The results obtained were compared with thoseobtained with the standard drug bleomycin.

Article Details

Antineoplastic Activities of Acetone Thiosemicarbazone against Ehrlich Ascites Carcinoma Cells Bearing Mice

Authors:

Mohammud M. Ali | Mele Jesmin | Mohammud K. Islam | Fatema Khatun | Abul K. Azad

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2013 vol.21 Issue 3, pp.97-104

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

39338

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0001498

Descriptors:

DISEASES

NEOPLASMS

LABORATORY ANIMALS

LEUKEMIA

ACETONE

ANTIBIOTICS

BLOOD CELLS

Anticancer activity

EAC cell

Schiff base

Acetone thiosemicarbazone

Issues

Article Details

Authors: Mohammud M. Ali | Mele Jesmin | Mohammud K. Islam | Fatema Khatun | Abul K. Azad

Publisher: Islamic World Academy of Sciences

Main Topics: Medicine

Journal: Medical Journal of Islamic World Academy of Sciences 2013 vol.21 Issue 3, pp.97-104

Document Type: Article

Publication Date: 7/2013

Document Language: English

Document ID (Org No.): 39338

Frequency: Quarterly

pISSN: 10163360

DOI: 10.12816/0001498

Descriptors:

Issues

Authors:

Mohammud M. Ali | Mele Jesmin | Mohammud K. Islam | Fatema Khatun | Abul K. Azad

Publisher:

Islamic World Academy of Sciences

Main Topics:

Medicine

Journal:

Medical Journal of Islamic World Academy of Sciences 2013 vol.21 Issue 3, pp.97-104

Document Type:

Article

Publication Date:

7/2013

Document Language:

English

Document ID (Org No.):

39338

Frequency:

Quarterly

pISSN:

10163360

DOI:

10.12816/0001498