The Synthesis and Antimicrobial Activity of \\\g-Butyrolactone Derivatives

Slobodan SUKDOLAK; Slavica SOLUJIC; Nenad VUKOVIC; Tanja MILOSEVIC

Article Details

The Synthesis and Antimicrobial Activity of \\\g-Butyrolactone Derivatives

Authors:

Slobodan SUKDOLAK | Slavica SOLUJIC | Nenad VUKOVIC | Tanja MILOSEVIC

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.615-621

Document Type:

Article

Publication Date:

4/2008

Document Language:

Turkish

Document ID (Org No.):

2000728449

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

This paper examines the synthesis of g-butyrolactone  compounds 2, 3, 4, 5, and 9, and their potential antimicrobial nature  and ability.  The structures of all the compounds mentioned above were  determined and confirmed with elemental analyses, and IR, 1H-NMR, and  13C-NMR spectroscopy.  The in vitro antimicrobial activity of  compounds 2, 3, 4, 5, and 9 was examined and evaluated against the  following pathogens: Enterobacter aerogenes, Enterobacter cloacae,  Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus,  Staphylococcus epidermidis, Streptococcus agalactiae, Aspergillus  niger, and Candida albicans.  Compound 5 (20 mg/mL) demonstrated high  antimicrobial activity against S. epidermidis, which was closely  comparable to the antimicrobial activity of streptomycin.

 

This paper examines the synthesis of g-butyrolactone  compounds 2, 3, 4, 5, and 9, and their potential antimicrobial nature  and ability.  The structures of all the compounds mentioned above were  determined and confirmed with elemental analyses, and IR, 1H-NMR, and  13C-NMR spectroscopy.  The in vitro antimicrobial activity of  compounds 2, 3, 4, 5, and 9 was examined and evaluated against the  following pathogens: Enterobacter aerogenes, Enterobacter cloacae,  Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus,  Staphylococcus epidermidis, Streptococcus agalactiae, Aspergillus  niger, and Candida albicans.  Compound 5 (20 mg/mL) demonstrated high  antimicrobial activity against S. epidermidis, which was closely  comparable to the antimicrobial activity of streptomycin.

Article Details

The Synthesis and Antimicrobial Activity of \\\g-Butyrolactone Derivatives

Authors: Slobodan SUKDOLAK | Slavica SOLUJIC | Nenad VUKOVIC | Tanja MILOSEVIC

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.615-621

Document Type: Article

Publication Date: 4/2008

Document Language: Turkish

Document ID (Org No.): 2000728449

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Slobodan SUKDOLAK | Slavica SOLUJIC | Nenad VUKOVIC | Tanja MILOSEVIC

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.615-621

Document Type:

Article

Publication Date:

4/2008

Document Language:

Turkish

Document ID (Org No.):

2000728449

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527