Efect of dual growth factor administration on oxidative markers   during acute stage wound healing in rats

BAHAR DİNDAR; KAAN KALTALIOĞLU; ŞULE COŞKUN CEVHER

Article Details

Efect of dual growth factor administration on oxidative markers during acute stage wound healing in rats

Authors:

BAHAR DİNDAR | KAAN KALTALIOĞLU | ŞULE COŞKUN CEVHER

Publisher:

TUBITAK

Journal:

Turkish Journal of Zoology 2017 Vol.41 Issue 5, pp.841-847

Document Type:

Article

Publication Date:

9/2017

Document Language:

Turkish

Document ID (Org No.):

2000773899

Frequency:

Bimonthly

eISSN:

1303-6114

pISSN:

1300-0179

Abstract:

 

Wound healing is a complex process affected by various conditions, including oxidative stress. The present study explored the time-dependent effects of platelet-derived growth factor (PGDF) and vascular endothelial growth factor (VEGF) administration on oxidative markers during acute stage wound healing. Thirty-six Wistar rats were distributed into three major groups; skin wounds were inflicted in all groups. The wounds were either left untreated (control group), treated topically with blank chitosan gel (blank chitosan gel group), or treated topically with a combination of PDGF and VEGF in chitosan gel (PDGF + VEGF chitosan gel group). Wounds were sampled on postsurgery days 3 and 7; samples were assayed for the oxidant markers nitric oxide (NOx) and thiobarbituric acid-reactive substances (TBARs) and the antioxidant markers glutathione (GSH), ascorbic acid (AA), and superoxide dismutase (SOD) activity. PDGF + VEGF administration increased and decreased NOx levels on days 3 and 7, respectively. PDGF + VEGF administration lowered TBARs levels, compared with blank chitosan gel administration, on day 7. PDGF + VEGF administration increased GSH levels. These results demonstrate that PDGF + VEGF administration changes oxidative status of wound tissue. This study provides valuable insights for the development of therapeutic targets that promote wound healing.

Article Details

Efect of dual growth factor administration on oxidative markers during acute stage wound healing in rats

Authors: BAHAR DİNDAR | KAAN KALTALIOĞLU | ŞULE COŞKUN CEVHER

Publisher: TUBITAK

Journal: Turkish Journal of Zoology 2017 Vol.41 Issue 5, pp.841-847

Document Type: Article

Publication Date: 9/2017

Document Language: Turkish

Document ID (Org No.): 2000773899

Frequency: Bimonthly

eISSN: 1303-6114

pISSN: 1300-0179

Issues

Authors:

BAHAR DİNDAR | KAAN KALTALIOĞLU | ŞULE COŞKUN CEVHER

Publisher:

TUBITAK

Journal:

Turkish Journal of Zoology 2017 Vol.41 Issue 5, pp.841-847

Document Type:

Article

Publication Date:

9/2017

Document Language:

Turkish

Document ID (Org No.):

2000773899

Frequency:

Bimonthly

eISSN:

1303-6114

pISSN:

1300-0179