Synthesis and Antimicrobial Evaluation of New 6 and7 Substituted Derivatives of Coumarin

Rouaa A. Muften; Kawkab Y.Saour; Ammar A.Razzak Mahmood

doi:10.31351/vol23iss1pp35-41

Article Details

Synthesis and Antimicrobial Evaluation of New 6 and7 Substituted Derivatives of Coumarin

Authors:

Rouaa A. Muften | Kawkab Y.Saour | Ammar A.Razzak Mahmood

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.23 Issue 1, pp.35-41

Document Type:

Article

Publication Date:

1/2014

Document Language:

English

Document ID (Org No.):

2001362705

pISSN:

2521-3512

DOI:

10.31351/vol23iss1pp35-41

Abstract:

 A series of benzohydrazide derivatives attached to coumarin moiety at position 6 and 7 have been synthesized. The reaction of coumarin derivatives (coumarin I and II) with p-nitrophenyl hydrazine yield Schiff bases (compound1a and IIa).These Schiff bases were refluxed with benzoyl chloride to give benzohydrazide derivatives of coumarin substituted at its 6 or 7 nucleus position (Ia1 and IIa1).The reaction and the purity of the products were checked by thin layer chromatography (TLC). The structures of the final compounds  and  their intermediates were confirmed by their melting points, infra red spectroscopy, and elemental microanalysis(CHN).
Compounds (Ia1 and IIa1) were evaluated for  their preliminary antibacterial and antifungal activities. Compound (IIa1) has good antibacterial activity against Staphylococcus aureus   other  than bacterial species, and was equivalent to ofloxacin as (standard drug).
Key word: Coumarin, Schiff base, benzohydrazide derivatives, antimicrobial activity.

Article Details

Synthesis and Antimicrobial Evaluation of New 6 and7 Substituted Derivatives of Coumarin

Authors: Rouaa A. Muften | Kawkab Y.Saour | Ammar A.Razzak Mahmood

Publisher: University of Baghdad

Journal: Iraqi Journal of Pharmaceutical Sciences Vol.23 Issue 1, pp.35-41

Document Type: Article

Publication Date: 1/2014

Document Language: English

Document ID (Org No.): 2001362705

pISSN: 2521-3512

DOI: 10.31351/vol23iss1pp35-41

Issues

Authors:

Rouaa A. Muften | Kawkab Y.Saour | Ammar A.Razzak Mahmood

Publisher:

University of Baghdad

Journal:

Iraqi Journal of Pharmaceutical Sciences Vol.23 Issue 1, pp.35-41

Document Type:

Article

Publication Date:

1/2014

Document Language:

English

Document ID (Org No.):

2001362705

pISSN:

2521-3512

DOI:

10.31351/vol23iss1pp35-41