Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats

Deniz ULUIŞIK; Ercan KESKİN; Durmuş HATİPOĞLU

Article Details

Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats

Authors:

Deniz ULUIŞIK | Ercan KESKİN | Durmuş HATİPOĞLU

Publisher:

Selcuk University

Main Topics:

Promotion of health

Journal:

Turkish Journal of Sport and Exercise 2020 Vol.22 Issue 2, pp.265-270

Document Type:

Article

Publication Date:

9/2020

Document Language:

English

Document ID (Org No.):

2000794192

Frequency:

Tri-annual

eISSN:

2147-5652

Abstract:

 

In this study, it is aimed to determine the possible effects of curcumin on hematological parameters in aflatoxin applied rats. Thirty eight healthy male Wistar Albino rats were used in the study. Group I animals was no applied. Animals in Group II were orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. At the end of the study, erythrocyte count, leukocyte count, platelet count, hemoglobin amount, hematocrit value, percentage ratios of leukocyte types, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined in blood samples taken from all animals. In the study, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC level in the aflatoxin applied rats significantly decreased compared to the control group (p<0.05). MCV level in the aflatoxin applied rats was found significantly higher compared to the control group (p<0.05). In the group in which aflatoxin and curcumin were administered together, erythrocytes count, hemoglobin concentration, hematocrit value and MCHC levels were found to be significantly higher compared to the group administered only aflatoxin (p<0.05). In the study, the leukocyte count significantly decreased in the aflatoxin group compared to the control group (p<0.05). Granulocyte and monocyte percentage significantly increased depend on aflatoxin application (p<0.05). In the group in which aflatoxin and curcumin were administered together, the leukocyte count significantly increased compared to the aflatoxin group (p<0.05). We concluded that curcumin may alleviate the abnormalities in hematological parameters resulting from aflatoxicosis.

Article Details

Effects of Curcumin on Hematological Parameters in Aflatoxin B1 Applied Rats

Authors: Deniz ULUIŞIK | Ercan KESKİN | Durmuş HATİPOĞLU

Publisher: Selcuk University

Main Topics: Promotion of health

Journal: Turkish Journal of Sport and Exercise 2020 Vol.22 Issue 2, pp.265-270

Document Type: Article

Publication Date: 9/2020

Document Language: English

Document ID (Org No.): 2000794192

Frequency: Tri-annual

eISSN: 2147-5652

Issues

Authors:

Deniz ULUIŞIK | Ercan KESKİN | Durmuş HATİPOĞLU

Publisher:

Selcuk University

Main Topics:

Promotion of health

Journal:

Turkish Journal of Sport and Exercise 2020 Vol.22 Issue 2, pp.265-270

Document Type:

Article

Publication Date:

9/2020

Document Language:

English

Document ID (Org No.):

2000794192

Frequency:

Tri-annual

eISSN:

2147-5652