Evaluation of Diagnostic Accuracy of the Approved Tumor Mapping Protocol in Grading of Glial Tumors

Nahid Sadighi; Sima Fallah Arzpeyma; Mohsen Izanlou; Mohamad Ali Oghabian; Mostafa Izanlou; Fateme Noori; Saeid Sadeghi Joni

doi:10.22317/jcms.v6i5.844

Article Details

Evaluation of Diagnostic Accuracy of the Approved Tumor Mapping Protocol in Grading of Glial Tumors

Authors:

Nahid Sadighi | Sima Fallah Arzpeyma | Mohsen Izanlou | Mohamad Ali Oghabian | Mostafa Izanlou | Fateme Noori | Saeid Sadeghi Joni

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.6 Issue 5, pp.249-254

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2001379368

pISSN:

2413-0516

DOI:

10.22317/jcms.v6i5.844

Keywords:

Abstract:

 Objective: Evaluation of Diagnostic Accuracy of the Approved Tumor Mapping Protocol in Grading of Glial Tumors.
Methods: This descriptive cross-sectional study was performed on patients aged 2 to 82 years with glial tumor. Patients were referred to the hospital for tumor mapping and underwent imaging with simultaneous methods of MRS and magnetic resonance (MR) perfusion and conventional MRI under the supervision of NIAG group. Then, the results of the second evaluation, including the ratios of the desired metabolites and the amount of blood flow, permeability of the target area were compared with the results of pathology. The results were analyzed by SPSS software version 24.
Results: In this study, 30 patients were included. Sensitivity, specificity, positive and negative predictive value for the determination of high-grade glioma with peripheral/internal rCBV were 100/100%, 100/93%, 93/100% and 100.100%, respectively. Sensitivity, specificity, positive and negative predictive value for the diagnosis of glioma by using peripheral/internal rCBV and thresholds of 2.65 and 1.06 were 100/100%, 93/100%, 93/100% and 100/100%, respectively. Sensitivity, specificity, positive predictive value and negative predictive value were determined for diagnosis of high-grade glioma tumor using Ch + Cr / NAA Cho / Cr and Cho / NAA ratios with detection threshold of 2.97 (93.3%), 3.5 (78.9%,100%, 100%, and 73.3%), and 2.1 (100%). Threshold values of 3.5, 2.1 and 2.97 were obtained using Cho / Cr, Ch + Cr / NAA and Cho / NAA, respectively, for the detection of high-grade gliomas. The combination of rCBV, Cho / Cr, Ch + Cr / NAA and Cho / NAA had sensitivity, specificity, positive and negative predictive value of 67.7%, 80%, 77% and 70.5%, respectively. Significant differences in rCBV and Cho / Cr, Cho / NAA and NAA / Cr ratios were observed between low- and high-grade gliomas (P <0.0001).
Conclusion: Preoperative grading of glioma based on routine MR imaging is often unreliable. As a result, measuring rCBV and Cho / Cr and Cho / NAA ratios independently and somewhat together can significantly improve the sensitivity and predictive values of preoperative glioma grading.

Article Details

Evaluation of Diagnostic Accuracy of the Approved Tumor Mapping Protocol in Grading of Glial Tumors

Authors:

Nahid Sadighi | Sima Fallah Arzpeyma | Mohsen Izanlou | Mohamad Ali Oghabian | Mostafa Izanlou | Fateme Noori | Saeid Sadeghi Joni

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.6 Issue 5, pp.249-254

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2001379368

pISSN:

2413-0516

DOI:

10.22317/jcms.v6i5.844

Brain tumor

glial tumor

tumor mapping protocol

tumor grading

Issues

Article Details

Evaluation of Diagnostic Accuracy of the Approved Tumor Mapping Protocol in Grading of Glial Tumors

Authors: Nahid Sadighi | Sima Fallah Arzpeyma | Mohsen Izanlou | Mohamad Ali Oghabian | Mostafa Izanlou | Fateme Noori | Saeid Sadeghi Joni

Publisher: Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal: Journal of Contemporary Medical Sciences Vol.6 Issue 5, pp.249-254

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 2001379368

pISSN: 2413-0516

DOI: 10.22317/jcms.v6i5.844

Brain tumor

glial tumor

tumor mapping protocol

tumor grading

Issues

Authors:

Nahid Sadighi | Sima Fallah Arzpeyma | Mohsen Izanlou | Mohamad Ali Oghabian | Mostafa Izanlou | Fateme Noori | Saeid Sadeghi Joni

Publisher:

Nab'a Al-Hayat Foundation for Medical Sciences and Health Care, Iraq

Journal:

Journal of Contemporary Medical Sciences Vol.6 Issue 5, pp.249-254

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

2001379368

pISSN:

2413-0516

DOI:

10.22317/jcms.v6i5.844